Sökning: "Neurochemistry and Molecular Neurobiology"
Visar resultat 11 - 15 av 80 avhandlingar innehållade orden Neurochemistry and Molecular Neurobiology.
11. Internalization mechanisms of cell-penetrating peptides : Structure-activity relationships, cellular distribution and membrane toxicity studies
Sammanfattning : Transport of substances with pharmaceutical potential over the plasma membrane has been pushed a great step forward with the discovery of short cationic polypeptides, known as cell-penetrating peptides (CPP). Since then, the internalization mechanism and cargo delivery properties of CPPs has been extensively studied. LÄS MER
12. Gene therapy tools: oligonucleotides and peptides
Sammanfattning : Genetic mutations can cause a wide range of diseases, e.g. cancer. Gene therapy has the potential to alleviate or even cure these diseases. LÄS MER
13. Specificity of antisense oligonucleotide derivatives and cellular delivery by cell-penetrating peptides
Sammanfattning : Atypical gene expression has a major influence on the disease profile of several severe human disorders. Oligonucleotide (ON) based therapeutics has opened an avenue for compensating deviant protein expression by acting on biologically important nucleic acids, mainly RNAs. LÄS MER
14. Processing of the APP family by the α-secretases ADAM10 and TACE
Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by formation of amyloid plaques in the brain. The major constituent of these plaques is the hydrophobic peptide Aβ. Aβ accumulation is considered to be the main cause of the pathology seen in AD brains. LÄS MER
15. Studies on Human and Drosophila melanogaster Glutathione Transferases of Biomedical and Biotechnological Interest
Sammanfattning : Glutathione transferases (GSTs, EC.2.5.1. LÄS MER