Sökning: "Neurochemistry and Molecular Neurobiology"
Visar resultat 16 - 20 av 80 avhandlingar innehållade orden Neurochemistry and Molecular Neurobiology.
16. Oxidative mechanisms in London Familial Alzheimer´s disease and LPS-induced inflammation
Sammanfattning : Alzheimer´s disease (AD) is the most common of the progressive neurodegenerative disorders and is characterized by the formation of Aβ deposits, neurofibrillary tangles and loss of neurons. Additional features of the disease are inflammation, increased oxidative stress and modified iron metabolism. LÄS MER
17. Structures, toxicity and internalization of cell-penetrating peptides
Sammanfattning : Cellular internalization is a highly regulated process controlled by proteins in the plasma membrane. Large and hydrophilic compounds, in particular, face difficulties conquering the plasma membrane barrier in order to gain access to intracellular environment. This puts serious constrains on the drug industry since many drugs are hydrophilic. LÄS MER
18. Chimeric gene delivery vectors : Design, synthesis, and mechanisms from transcriptomics analysis
Sammanfattning : Delivery of nucleic acid is a promising approach for genetic diseases/disorders. However, gene therapy using oligonucleotides (ONs) suffers from low transfection efficacy due to negative charges, weak cellular permeability, and enzymatic degradation. LÄS MER
19. RNA binding proteins and epigenetics in SCA7
Sammanfattning : Polyglutamine diseases are a group of nine disorders that includes, among others SCA7. The common denominator is an expanded glutamine tract in the respective disease protein caused by unstable replication during meiosis. LÄS MER
20. The adaptor protein Fe65 and APP processing
Sammanfattning : The amyloid precursor protein (APP) protein has been in the limelight of research on Alzheimer´s disease (AD) pathogenesis because its proteolytic processing gives rise to the neurotoxic amyloid β (Aβ) peptide, the main constituent of amyloid plaques in the brains of AD patients. APP is sequentially processed by at least three different proteases termed α-, β-, and γ-secretases. LÄS MER