Sökning: "oligonucleotide derivative"

Hittade 5 avhandlingar innehållade orden oligonucleotide derivative.

1. 1. Specificity of antisense oligonucleotide derivatives and cellular delivery by cell-penetrating peptides

   Författare :Peter Guterstam; Ülo Langel; Matthew Wood; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cell-penetrating peptide; splice-switching oligonucleotide; oligonucleotide derivative; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Atypical gene expression has a major influence on the disease profile of several severe human disorders. Oligonucleotide (ON) based therapeutics has opened an avenue for compensating deviant protein expression by acting on biologically important nucleic acids, mainly RNAs. LÄS MER

3. 2. Synthesis of 18F- and 76Br-labelled oligonucleotide and nucleoside derivatives

   Författare :Elisabeth Hedberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

   Sammanfattning : With the aim of developing synthetic routes to oligodeoxynucleotides and analogues labelled with the positron-emitting radionuclides 18F and 76Br (half-lives 1.8 and 16. LÄS MER

4. 3. Conformationally Constrained Nucleosides : Design, Synthesis, and Biochemical Evaluation of Modified Antisense Oligonucleotides

   Författare :Oommen P. Varghese; Lars Engman; Jacek Stawinski; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; chemically modified oligonucleotides; azetidine; aza-ENA-T; cyanomethylene locked; free energy of activation; diaxial interactions; chair conformation; stable duplex; human serum; snake venom phosphodiesterase; antisense agents; RNase H; Organisk kemi; Chemistry; Kemi;

   Sammanfattning : This thesis is concerned with synthesis, structure and biochemical analysis of chemically modified oligonucleotides with potential therapeutic applications. The three types of chemical modifications described here are: (a) A North-East locked 1',2'-azetidine nucleoside (b) A North locked 2',4'-cyanomethylene bridged nucleoside and (c) A 2',4'-aza-ENA-T nucleoside. LÄS MER

5. 4. Dissecting the p53 pathway by means of small molecule-mediated reactivation and computational biology

   Författare :Martin Enge; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The p53 tumor suppressor is a highly connected signaling molecule with paramount importance to tumor suppression. It is activated by diverse stress signals and in response activates the transcription of affector genes that can induce several cellular processes, most importantly cell-cycle arrest and apoptosis. LÄS MER

7. 5. Applications of Chromophores and Multiphoton Techniques to Study Structure and Interactions of Bio-macromolecules in Assembled State

   Författare :Piotr Hanczyc; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Z-scan; One-photon spectroscopy; oxazole yellow dyes; two-photon absorption.; non-linear spectroscopy; PVA DNA dyes films; linear dichroism; ruthenium complexes;

   Sammanfattning : The research presented in this thesis is concerned with the linear and nonlinear optical properties of biopolymers and the chromophores that bind to them. This thesis combines analyses of the interactions of biomolecules with technological improvements of already existing systems for bionanotechnology-related research. LÄS MER