Sökning: "NMDA receptor antagonists"

Visar resultat 11 - 15 av 28 avhandlingar innehållade orden NMDA receptor antagonists.

  1. 11. Neuropeptide release in the rat dorsal horn in models of persistent pain : effects of opioids

    Författare :Abdullahi Warsame Afrah; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Axotomy; Inflammation; Long term potentiation; Capsaicin; Opioids; Cholecystokinin; Substance P; Glutamate; NMDA; Spinal cord; Microdialysis; Radioimmunoassay.;

    Sammanfattning : Nerve injury and tissue inflammation may lead to exaggerated responses to both noxious stimuli (hyperalgesia) and innocuous stimuli (allodynia). Altered release pattems of neurotransmitters in the dorsal hom of the spinal cord have been suggested to contribute to hyperalgesia and allodynia. LÄS MER

  3. 12. The diagnosis and protection of the auditory peripheral system

    Författare :Mao Li Duan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cochlea; inner hair cell; outer hair cell; glutamate; post-synaptic receptor; auditory brainstem response; forward masking; noise trauma; hearing loss;

    Sammanfattning : The main focus of this thesis is on the diagnosis and prevention of peripheral hearing loss. An auditory evoked response measure (forward masking) was developed that specifically tests the function of the inner hair cells, independently of the outer hair cells. LÄS MER

  4. 13. Mechanism of action of antipsychotic drugs : focus on the nucleus accumbens and the prefronta cortex : an experimental study

    Författare :Monica M Marcus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; antipsychotic drug; nucleus accumbens shell; nucleus accumbens core; prefrontal cortex; dopamine; 5-11T2A receptor; alpha1 adrenoceptor; C12 adrenoceptor; glutamate; nicotine.;

    Sammanfattning : Antipsychotic drugs have been classified as typical or atypical. To achieve an effective antipsychotic effect with typical antipsychotic drugs, e.g. haloperidol, a dopamine D2 receptor blockade of about 70% seems necessary. LÄS MER

  5. 14. Regulation by glutamate- and adenosine-receptors of dopamine and acetylcholine release from rat striatal slices

    Författare :Shaoyu Jin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :striatum; dopamine; acetylcholine; adenosine receptors; glutamatereceptors. ISBN 91-628-2599-2;

    Sammanfattning : The striatum, which is critically involved in sensory motor integration, receives an excitatory glutamatergic input from the cerebral cortex and the thalamus. The effects of the glutamatergic stimulation are modulated by dopamine (DA) released from a prominent dopaminergic input, acetylcholine (ACh) released from cholinergic interneurons and by the ubiquitous neuromodulator adenosine. LÄS MER

  7. 15. Mechanisms of opiate tolerance and dependence in the rat

    Författare :Orsolya Hoffman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Drug addiction is a complex phenomenon with various biological, psychological and social causes and consequences, which belongs to the major problems of today's society. Opiates have been used and misused for thousand of years and addiction to them develops both in humans and in animals. LÄS MER