Sökning: "NMDA receptor antagonists"

Visar resultat 16 - 20 av 28 avhandlingar innehållade orden NMDA receptor antagonists.

  1. 16. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

    Författare :Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. LÄS MER

  3. 17. Ischemic Cell Death in the CNS - applications of a new in vitro model

    Författare :Tobias Cronberg; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; Neurologi; Neurology; astrocyte; stroke; adenosine; hyperglycaemia; glucose; free radicals; calcium; in vitro; brain ischemia; slice; neuropsychology; neurofysiologi; neurophysiology;

    Sammanfattning : Ischemic brain damage is a common cause of death and disability. A global ischemic insult is usually the result of a transient cardiac arrest while occlusion of cerebral blood vessels leads to focal ischemic lesions, commonly termed stroke. LÄS MER

  4. 18. Brain immune mechanisms in schizophrenia : experimental and clinical characterization

    Författare :Maximilian Tufvesson Alm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The role of inflammation has become increasingly evident in the pathophysiology of schizophrenia and thought to one of the major causes of the symptoms. Interestingly, immune activation has been linked to the kynurenine pathway of tryptophan degradation, which produces an array of neuroactive metabolites. LÄS MER

  5. 19. Comparative genome and proteome analysis of brain tissue from MK-801-treated rats

    Författare :Linda Paulson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Schizophrenia; MK-801; rat; animal model; proteomics; genomics;

    Sammanfattning : Symptoms of intoxication with non-competitive N-methyl-D-aspartate (NMDA)-receptor antagonists, closely mimic symptoms in patients with schizophrenia, and therefore [+]-5-methyl-10,11-dihydro-5H-dibenzo-[a,d]-cycloheptene-5,10-iminehydrogen-maleate (MK-801, dizocilpine) treated rodents are often used as a model for schizophrenia. To investigate if administration of the NMDA receptor antagonist MK-801 to rats would induce messenger ribonucleic acid (mRNA) or protein disturbances mimicking those observed in schizophrenic patients, complementary deoxyribonucleic acid (cDNA) microarrays and two-dimensional gel-electrophoresis in combination with mass spectrometry were used, respectively. LÄS MER

  7. 20. Neuronal apoptosis in excitotoxicity : involvement of nitric oxide and cytoskeletal damage

    Författare :Emanuela Bonfoco; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In the nervous system apoptosis may play an important role in the development of several neurodegenerative diseases. The overall objective of the present work is to investigate at the cellular and molecular levels, the mechanisms by which neurons are signaled to undergo apoptotic cell death after exposure to various effectors, such as nitric oxide (NO) and its byproducts, glutamate, and colchicine. LÄS MER