Sökning: "nucleus accumbens core"

Hittade 5 avhandlingar innehållade orden nucleus accumbens core.

  1. 1. Mechanism of action of antipsychotic drugs : focus on the nucleus accumbens and the prefronta cortex : an experimental study

    Författare :Monica M Marcus; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; antipsychotic drug; nucleus accumbens shell; nucleus accumbens core; prefrontal cortex; dopamine; 5-11T2A receptor; alpha1 adrenoceptor; C12 adrenoceptor; glutamate; nicotine.;

    Sammanfattning : Antipsychotic drugs have been classified as typical or atypical. To achieve an effective antipsychotic effect with typical antipsychotic drugs, e.g. haloperidol, a dopamine D2 receptor blockade of about 70% seems necessary. LÄS MER

  3. 2. Dopamine receptors in the rat brain

    Författare :Mi Hillefors-Berglund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine D2 receptors; Dopamine D3 receptors; Rat; Autoradiography; [3H]7-OH-DPAT; [3H]PD 128907; Caudate-putamen; Subcortical limbic area; Islands of Calleja; CGS 21680; Toluene; Neurotensin; Asphyxia; Aging; Magnesium; GTP;

    Sammanfattning : Dopamine receptors belong to a large superfamily of G protein-coupled receptors and consist of the D1, D2, D3, D4, and D5 receptors. The D2, D3, and D4 receptors belong to the D2 receptor family which is characterized by having a large third cytoplasmic loop and a short C-terminus projecting into the cytosol, and by inhibiting the enzyme adenylyl cyclase. LÄS MER

  4. 3. Effects of joint cocaine and ethanol on the brain opioid systems

    Författare :Åsa Rosin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cocaine; ethanol; co-abuse; opioid system; dopamine; nociccptin;

    Sammanfattning : Concurrent abuse of cocaine and alcohol is common among human addicts, where 85% of all cocaine users have also been shown to meet the criteria for alcohol dependence. Concurrent abuse of cocaine and alcohol is associated with a more severe dependence and a more pronounced abstinence than using either drug alone. LÄS MER

  5. 4. Modulation of prefrontal glutamatergic transmission and 'atypicality' of antipsychotic drugs

    Författare :Åsa Konradsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The glutamate hypothesis of schizophrenia suggests a relationship between hypoactive NMDA receptor-mediated glutamatergic transmission and the pathophysiology of schizophrenia. Previous results have demonstrated that atypical (e.g. clozapine, risperidone, and olanzapine), but not typical (e. LÄS MER

  7. 5. The role of the dopamine system in the ability of (-)-OSU6162 to reduce voluntary alcohol drinking and binge-eating in the rat

    Författare :Kristin Feltmann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : BACKGROUND AND AIMS: The dopamine system is involved in the reinforcing effects of both food and alcohol and is thus a potential treatment target for alcohol use disorder (AUD) and binge-eating disorder (BED). Alcohol use disorder is characterized by difficulties to control alcohol drinking and by drinking despite adverse consequences. LÄS MER