Sökning: "NMDA receptor antagonists"

Visar resultat 21 - 25 av 28 avhandlingar innehållade orden NMDA receptor antagonists.

  1. 21. Nerve injury induced pain and spinal cord stimulation

    Författare :Camilla Ultenius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neuropathic pain;

    Sammanfattning : Chronic neuropathic pain caused by injury to or disease in the nervous system is relatively common and results in major suffering, poor quality of life and incapacity. Such pain is a therapeutic challenge because a considerable portion of the patients fails to benefit from pharmacotherapy. LÄS MER

  3. 22. Modulation by substance P in the lamprey spinal cord

    Författare :Carolina Thörn Pérez; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neuromodulation is a key element for animal adaptation to environmental circumstances. Neuromodulators can alter the output of a physiological system by acting on the motor circuit by transforming intrinsic firing properties and altering synaptic strength. Substance P belongs to the family of tachykinin, which are peptidergic neuromodulators. LÄS MER

  4. 23. Ischemic brain damage following transient and moderate compression of sensorimotor cortex in Sprague-Dawley and diabetic Goto-Kakizaki rats

    Författare :Jurgita Kundrotiené; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cortical compression; cerebral ischemia; neuroprotection; hyperglycemia; GotoKakizaki rats.;

    Sammanfattning : Several animal models have been developed to facilitate the investigation of biochemical, physiological, and neurological events after cerebral ischemia. In this study we present a new animal model which reliably describes morphological changes and neurological deficits produced by mild to moderate brain ischemia and which can be used to identify novel, potentially useful, neuroprotective agents. LÄS MER

  5. 24. Movement pattern analysis of hypoglutamatergic mice. A model for cognitive deficits of schizophrenia and autism?

    Författare :Marie Nilsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; autism; cognition; movement pattern; video tracking; MK-801; mice;

    Sammanfattning : Schizophrenia and autism are two severe neuropsychiatric disorders that are associated withprofound cognitive disturbances which considerably contribute to the long-term morbidity andthe decreased ability to function in the society. Currently used therapies do not reach the corecognitive disturbances to a satisfactory extent. LÄS MER

  7. 25. Region-specific expression of the interleukin-1 system in rat brain following endotoxin challenge and excitotoxic neurodegeneration

    Författare :Charlotta Eriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Traditionally, up-regulation and secretion of cytokines are associated with peripheral immune and inflammatory responses. There is now evidence that cytokines also exert various actions in the central nervous system (CNS). LÄS MER