Sökning: "antipsychotic drug"

Visar resultat 1 - 5 av 48 avhandlingar innehållade orden antipsychotic drug.

1. 1. Potentially inappropriate drug treatment among older people with cognitive impairment

   Författare :Eva Sönnerstam; Maria Gustafsson; Maria Sjölander; Hugo Lövheim; Ylva Böttiger; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Older people; major neurocognitive disorder; cognitive impairment; potentially inappropriate medications; drug-drug interactions; renal function; adverse drug reactions; nursing homes; time trends; Clinical Pharmacology; klinisk farmakologi;

   Sammanfattning : Background: The aging process contributes to alterations in organ systems, which lead to an increased risk for chronic conditions. Drug treatment is an important strategy in the management of chronic conditions; however, pharmacokinetic and pharmacodynamic alterations contribute to increased sensitivity to drug effects. LÄS MER

3. 2. Drug Repositioning for Cancer Treatment : Novel Candidate Identification Strategies

   Författare :Madiha Nazir; Mårten Fryknäs; Sigurd Vitols; Uppsala universitet; []
   Nyckelord :cancer treatment; drug repositioning; Phosphodiesterase 3A PDE3A ; apoptosis; combination screening;

   Sammanfattning : Regardless of the enormous investments in cancer research and drug development, the proportion of approved drugs in oncology is low compared to other indications, and new avenues are needed. One attractive approach in this regard is drug repositioning where new uses outside the scope of the original medical indications for existing drugs are identified. LÄS MER

4. 3. Therapeutic Drug Monitoring in Psychiatry : Some aspects of utility in clinical practice and research

   Författare :Maria Dolores Chermá Yeste; Finn Bengtsson; Johan Ahlner; Ylva Böttiger; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TDM; psychoactive drug; pharmacokinetics; pharmacogenetics; naturalistic; elderly; child; Clinical pharmacology; Klinisk farmakologi;

   Sammanfattning : Background and objectives: Several new psychoactive drugs for the treatment of psychiatric disorders have been introduced onto the market since the late 1980s. Basic aspects of pharmacodynamics and pharmacokinetics (PK) are investigated before approval for general prescription. LÄS MER

5. 4. Optimizing drug therapy among people with dementia : the role of clinical pharmacists

   Författare :Maria Gustafsson; Hugo Lövheim; Maria Sjölander; Jörn Schneede; Stig Karlsson; Håkan Melhus; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Psychotropic drugs; potentially inappropriate drugs; drug-related problems; old people; dementia; nursing homes; drug-related hospitalizations; medication reviews; clinical pharmacists; geriatrik; Geriatrics;

   Sammanfattning : Background: Drugs are one of the cornerstones in the management of many diseases. In general, drugs are used for diagnosis, prevention, mitigation of symptoms, and, sometimes, to cure disease. However, drug treatment in elderly people, especially those with dementia and cognitive impairments, may involve significant risk of adverse drug events. LÄS MER

7. 5. Drug-related morbidity and mortality : Pharmacoepidemiological aspects

   Författare :Anna K. Jönsson; Staffan Hägg; Johan Ahlner; Henrik Druid; Jörg Mörland; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Adverse drug reactions; pharmacoepidemiology; antipsychotics; venous; thromboembolism; warfarin; haemorrhage; intoxication; medico-legal autopsies; mortality; Läkemedelsbiverkningar; farmakoepidemiologi; antipsykotika; venös tromboembolism; warfarin; blödning; intoxikation; rättsmedicinska obduktioner; fatal; Clinical pharmacology; Klinisk farmakologi;

   Sammanfattning : Adverse drug reactions (ADRs) constitute a significant health problem with consequences for the patient as well as for society. Suspected ADRs have been reported to occur in about 2-14% of hospitalised patients. In about 5% of deceased hospitalised patients suspected ADRs may have caused or contributed to the fatal outcome. LÄS MER