Sökning: "outer hair cell"
Visar resultat 1 - 5 av 20 avhandlingar innehållade orden outer hair cell.
1. The role of Lhx2 in hair follicle morphogenesis and regeneration
Sammanfattning : Hair is important for thermoregulation, physical protection, sensory activity, seasonal camouflage and social interactions. Hair is produced in hair follicles (HFs), complex mini-organs in the skin devoted to this task. LÄS MER
2. Hair cell and organ of corti responses to normal and intense acoustic stimulation
Sammanfattning : The principal aims of the studies described in this thesis were to develop an in vitro model for studying acoustic overstimulation at the cellular level, to define the electrical and mechanical response characteristics of the perfused temporal bone preparation, and to investigate the effects of intense sound stimulation on the calcium levels of the hair cells in the intact hearing organ. In the in vitro model for acoustic overstimulation, isolated cochlear outer hair cells were subjected to a pressure jet emanating from a glass micropipette aimed at the cell body. LÄS MER
3. Development of a mouse model for Hutchinson-Gilford progeria syndrome reveal defects in adult stem cell maintenance
Sammanfattning : Hutchinson-Gilford progeria syndrome (HGPS) is a very rare genetic disease that presents some features of accelerated aging. Children with the disease are born appearing healthy but start to develop signs of the disease within their first years of life. LÄS MER
4. The diagnosis and protection of the auditory peripheral system
Sammanfattning : The main focus of this thesis is on the diagnosis and prevention of peripheral hearing loss. An auditory evoked response measure (forward masking) was developed that specifically tests the function of the inner hair cells, independently of the outer hair cells. LÄS MER
5. Thyroid hormone mediates fibroblast growth factor receptor expression, which both alter cell surface mechanical properties of the mammalian cochlea
Sammanfattning : Cells in the mammalian hearing organ, the cochlea, develop a specialized patterning and cellular architecture necessary for hearing function. Cytoskeletal components, such as actin and microtubules, maintain the material and mechanical properties of these cells. LÄS MER