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Visar resultat 1 - 5 av 7 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Nuclear hormone receptor signaling in the developing CNS : studies on the retinoid receptors RAR and RXR, and the orphan receptors NURR1, NOR1 and NGFI-B

   Författare :Ludmila Solomin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The nuclear hormone receptor superfamily comprises more than sixty members, including receptors for steroids, thyroid hormone, vitamin D and retinoids. Many nuclear receptors function as ligand-induced transcription factors that upregulate expression of specific target genes. LÄS MER

3. 2. On retinoid receptors, Nurr1 and related transcription factors in the CNS

   Författare :Rolf H Zetterström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Nurr1; NGFI-B; Nor1; RAR; RXR; CRBP; CRABP; substantia nigra; basal ganglia; dopamine; orphan receptor; vitamin A; retinoic acid; transcription factor;

   Sammanfattning : It has long been known that retinoids (vitamin A derivatives) are required for normal development and growth; in excess however metabolites such as all-trans retinoic acid are potent teratogens. Retinoids exert their effects through transcription factors known as the retinoic acid receptors (RARam -ß and -y) and retinoid X receptors (RXRa, -ß and -y). LÄS MER

4. 3. Stroke and Functional Recovery - An experimental study on environmental influence and gene expression after cortical infarcts in the rat

   Författare :Anette Risedal; Lund Neurologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; cortical infarct; rat; enriched environment; functional recovery; brain-derived neurotrophic factor; inducible transcription factors; neuropsykologi; neurofysiologi; Neurologi; glucocorticoids; neurophysiology;

   Sammanfattning : Abstract Stroke is the third leading cause of death in the western world, and the number one cause of disability. 85% of all strokes are ischemic. Most stroke survivors will experience recovery of function. The mechanisms behind this improvement are partly unknown, but may involve elements of both compensation and restoration. LÄS MER

5. 4. The effect of enriched environment on gene expression and stroke recovery

   Författare :Annica Rönnbäck; Tommy Olsson; Peter Eriksson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; experimental stroke; recovery; memory; inducible transcription factors; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

   Sammanfattning : Stroke is the third leading cause of death and the major course of long-term disabilities in industrialized countries. Most surviving stroke patients show some degree of spontaneous recovery, but persistent symptoms in sensorimotor and cognitive functions are common. LÄS MER

7. 5. On natural and drug-induced reward : genetic, biochemical and behavioral comparisons

   Författare :Martin Werme; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :VTA; nucleus accumbens; wheel running; exercise; drugs of abuse; addiction; compulsive; deltaFosB; Nurr1; Dynorphin;

   Sammanfattning : Work in this thesis compares natural and drug- induced reward at genetic, biochemical and behavioral levels with the objective to obtain information about key mechanisms underlying reward and addiction, and improve the understanding of compulsive elements that characterize addiction. Surveys among committed human runners have described running as addictive. LÄS MER