Sökning: "NATURAL SCIENCES Biology Cell and molecular biology Neurobiology"
Visar resultat 1 - 5 av 21 avhandlingar innehållade orden NATURAL SCIENCES Biology Cell and molecular biology Neurobiology.
1. Models of Retinal Development and Disease
Sammanfattning : For a model of a human disease to be valid and useful, it is important that key genotypic and phenotypic traits are shared between model system and human. The work in this thesis has been focused on generating new and characterizing spontaneous models of three genetic disorders affecting the retina: retinoblastoma, a childhood cancer with its origin in the fetal retina, Stargardt disease, a juvenile form of macular degeneration, and Bardet-Biedl syndrome, a pleiotropic ciliopathy featuring retinal degeneration. LÄS MER
2. Imaging the molecular pathways of neurodegeneration : New pathologies of SCA7
Sammanfattning : Spinocerebellar Ataxia type 7 (SCA7) is a genetic neurodegenerative disease with lethal outcome that affects the cerebellum and retina of patients. This thesis focuses on characterising molecular pathological pathways that cause toxicity and cell death in SCA7. LÄS MER
3. Identification and characterization of nuclear envelope protein interactions
Sammanfattning : The Nuclear envelope which surrounds the chromatin of eukaryotic cells contains more than a hundred transmembrane proteins. Mutations in some genes encoding nuclear envelope proteins give rise to human diseases including neurological disorders. The function of many nuclear envelope proteins is not well established. LÄS MER
4. Multifaceted roles of the transmembrane nuclear envelope protein, Samp1
Sammanfattning : The eukaryotic nuclear envelope (NE), separates the nucleoplasm from cytoplasm and is made up of two concentric lipid membranes, the outer and the inner nuclear membranes (ONM and INM), the nuclear pore complexes (NPCs) and an underlying filamentous nuclear lamina. The INM contains hundreds of unique transmembrane proteins of which only a handful have been characterized. LÄS MER
5. Caspase activation in human neuroblastoma cells: mechanisms and spatiotemporal aspects
Sammanfattning : Apoptosis is one of the modes of programmed cell death, in which several members of the caspase family of proteases play the central role. However, activation of apoptotic caspases does not necessarily lead to cell death. LÄS MER