Sökning: "transmembrane protein interaction studies"

Visar resultat 1 - 5 av 46 avhandlingar innehållade orden transmembrane protein interaction studies.

1. 1. Nuclear envelope protein interaction studies

   Författare :Mohammed Hakim Jaffer Ali; Einar Hallberg; Anki Östlund-Farrants; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Samp1; Nuclear envelope; protein interactions; chemical crosslinking; proteomics; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The nuclear envelope (NE) separating the nucleoplasm from cytoplasm consists of two concentric lipid membranes, the outer (ONM) and inner (INM) nuclear membranes, the nuclear pore complexes (NPCs) and an underlying nuclear lamina network. The INM contains more than 100 unique transmembrane proteins of which only a few have been characterized. LÄS MER

3. 2. Nanosized Bilayer Disks as Model Membranes for Interaction Studies

   Författare :Anna Lundquist; Katarina Edwards; Marja-Liisa Riekkola; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Disk; disc; lipid bilayer; PEG-lipid; model membrane; interaction; partitioning; drug; liposome; cryo-TEM; neutron scattering; capillary electrophoresis; immobilization; biosensor; membrane protein; melittin; Chemistry; Kemi;

   Sammanfattning : PEG-lipid stabilized bilayer disks have been found in lipid mixtures containing polyethylene glycol (PEG)-lipids where the combination of a high bending rigidity and low PEG-lipid/lipid miscibility favours disk formation. The disks are planar and circular in shape and their long-term stability is excellent. LÄS MER

4. 3. Multifaceted roles of the transmembrane nuclear envelope protein, Samp1

   Författare :Mohammed Hakim Jaffer Ali; Einar Hallberg; Giovanna Lattanzi; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Nuclear envelope; transmembrane protein interaction studies; cell differentiation; stem cells; myopathies; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The eukaryotic nuclear envelope (NE), separates the nucleoplasm from cytoplasm and is made up of two concentric lipid membranes, the outer and the inner nuclear membranes (ONM and INM), the nuclear pore complexes (NPCs) and an underlying filamentous nuclear lamina. The INM contains hundreds of unique transmembrane proteins of which only a handful have been characterized. LÄS MER

5. 4. Protein Interaction Studies with Low Molecular Weight Ligands : Applications for Drug Discovery, Basic Research and Diagnostic Tool Design

   Författare :Tony Christopeit; U.Helena Danielson; Danièle Altschuh; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : In this thesis, the interactions between different proteins and small ligands were characterized by surface plasmon resonance spectroscopy (SPR) and fluorescence resonance energy transfer (FRET) based assays.   For the C-reactive protein (CRP), a new type of artificial binder was identified which allows designing diagnostic assays superior to commonly used standard assays. LÄS MER

7. 5. Characterization and Evolution of Transmembrane Proteins with Focus on G-protein coupled receptors in Pre-vertebrate Species

   Författare :Karl J. V. Nordström; Helgi B. Schiöth; Robert Fredriksson; Teresa Attwood; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; G protein-coupled receptors; GPCR; Membrane protein; Rhodopsin; Adhesion; Secretin; Evolution; Bioinformatics; Phylogeny; Pharmacological research; Farmakologisk forskning; Bioinformatics; Bioinformatik; Bioinformatik; Bioinformatics; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

   Sammanfattning : G protein-coupled receptors (GPCRs) are one of the largest protein families in mammals. GPCRs are instrumental for hormonal and neurotransmitter signalling and are important in all major physiological systems of the body. LÄS MER