Sökning: "Michael Gait"

Hittade 5 avhandlingar innehållade orden Michael Gait.

  1. 1. Structures, toxicity and internalization of cell-penetrating peptides

    Författare :Emelía Eiríksdóttir; Ülo Langel; Michael Gait; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CPP; cell-penetrating peptide; internalization; toxicity; structures; Neurochemistry; Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : Cellular internalization is a highly regulated process controlled by proteins in the plasma membrane. Large and hydrophilic compounds, in particular, face difficulties conquering the plasma membrane barrier in order to gain access to intracellular environment. This puts serious constrains on the drug industry since many drugs are hydrophilic. LÄS MER

  3. 2. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery : Applications and mechanisms

    Författare :Henrik Johansson; Ülo Langel; Michael Gait; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; cell-penetrating peptide; PNA; splicing; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

    Sammanfattning : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. LÄS MER

  4. 3. Cell-penetrating peptides and bioactive cargoes : Strategies and mechanisms

    Författare :Kalle Kilk; Ülo Langel; Michael J. Gait; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell-penetrating peptide; delivery; Peptide nucleic acid; Biochemistry; Biokemi;

    Sammanfattning : The cell membrane is an impermeable barrier for most macromolecules. Recently discovered cell-penetrating peptides (CPPs) have gained lot of attention because they can cross the membrane, and even more, carry cargoes with them. How CPPs enter cells is still not clear, while the delivery of different cargoes has been convincingly shown. LÄS MER

  5. 4. Cerebral white matter changes in patients with cognitive impairment - clinical and pathophysiological aspects

    Författare :Michael Jonsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; white matter changes; vascular factors; cognitive impairment; neuropsychiatric symptoms; cerebrospinal fluid biomarkers; demyelination; axonal degeneration;

    Sammanfattning : Cerebral white matter changes (WMC), detected with computed tomography (CT) or magnetic resonance imaging (MRI), represent a common condition in elderly people. However, the prognostic, symptomatological and biochemical constituents of WMC are only partially known. LÄS MER

  7. 5. Team-based home rehabilitation after hip fracture in older adults : effects, experiences and impact of dementia

    Författare :Åsa Karlsson; Nina Lindelöf; Birgitta Olofsson; Michael Stenvall; Yngve Gustafson; Peter Nordström; Anna Cristina Åberg; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; hip fracture; geriatrics; dementia; home rehabilitation; interdisciplinary rehabilitation; walking ability; activities of daily living; recovery; length of stay; accidential falls; qualitative; Geriatrics; geriatrik; Orthopaedics; ortopedi;

    Sammanfattning : BACKGROUND: For an older adult a hip fracture may be a traumatic and life-changing event and has shown to be associated with reduced health-related quality of life, disability and increased mortality. Previous rehabilitation studies have often excluded older adults with cognitive impairment and those living in residential care facilities, groups with an additional risk of poor outcome. LÄS MER