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Visar resultat 1 - 5 av 260 avhandlingar som matchar ovanstående sökkriterier.

1. 1. Metabolomics and proteomics studies of brain tumors : a chemometric bioinformatics approach

   Författare :Lina Mörén; Henrik Antti; Anders Malmendal; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; glioma; meningioma; metabolomics; proteomics; mass-spectrometry; biologisk kemi; biological chemistry;

   Sammanfattning : The WHO classification of brain tumors is based on histological features and the aggressiveness of the tumor is classified from grade I to IV, where grade IV is the most aggressive. Today, the correlation between prognosis and tumor grade is the most important component in tumor classification. LÄS MER

3. 2. Molecular mechanisms in obesity-associated metabolic disease

   Författare :Louise Olofsson; Göteborgs universitet; []
   Nyckelord :obesity; metabolic syndrome; cholesterol; resting metabolic rate; insulin resistance; serum amyloid A; S100 calcium binding protein A1; Zn-alpha2-glycoprotein; CCAAT enhancer binding protein alpha;

   Sammanfattning : Obesity is associated with increased morbidity and mortality. Subjects with obesity are at risk of developing several serious conditions such as type 2 diabetes, hypertension, coronary heart disease and stroke. LÄS MER

4. 3. On metabolic networks and multi-omics integration

   Författare :Rasmus Ågren; Chalmers tekniska högskola; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

   Sammanfattning : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. LÄS MER

5. 4. Analysis of Metabolites in Complex Biological Samples Using LC/MS and Multivariate Data Analysis : Metabolic Fingerprinting and Detection of Biomarkers

   Författare :Helena Idborg; Sven Jacobsson; Per-Olof Edlund; Jonas Bergquist; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Metabolomics; Metabonomics; Metabolic Fingerprinting; Drug Metabolism; Biomarkers; Human Plasma; Rat Urine; LC MS; ZIC-HILIC; UPLC; UHPLC; ToF; Curve Resolution; Peak Detection; Pattern Recognition; Classification; PCA; PLS; PARAFAC; N-PLS; Data Fusion; Hierarchical Modeling; Batch modeling; Data Concatenation; Breast Cancer; Phospholipidosis; Analytical chemistry; Analytisk kemi; Analytical Chemistry; analytisk kemi;

   Sammanfattning : To facilitate early diagnosis of diseases and elucidation of the processes involved in their development and progression, various specific compounds or ‘biomarkers’ are often monitored. The first step is to decide which compounds to analyze. LÄS MER

7. 5. Mapping the consequenses of physical exercise and nutrition on human health : A predictive metabolomics approach

   Författare :Elin Chorell; Henrik Antti; Lorraine Brennan; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Metabolomics; physical exercise; cardiorespiratory fitness nutrition; high protein and fat diet; Lactobacillus F19; probiotics; GC-MS; plasma; chemometrics; multivariate analysis statistical experimental design; design of experiments; Chemistry; Kemi; Systems Analysis; systemanalys; näringslära; Nutrition; molecular medicine medical sciences ; molekylär medicin medicinska vetenskaper ;

   Sammanfattning : Human health is a complex and wide-ranging subject far beyond nutrition and physical exercise. Still, these factors have a huge impact on global health by their ability to prevent diseases and thus promote health. LÄS MER