Sökning: "MHC region"

Visar resultat 21 - 25 av 68 avhandlingar innehållade orden MHC region.

  1. 21. Structural studies of metal-binding proteins revealing dynamic behaviour

    Författare :Maria Håkansson; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Chemistry; Molekylär biofysik; Molecular biophysics; zinc; magnesium; superantigen; calbindin D9k; X-ray crystallography; staphylococcal enterotoxin; structure; Chemical technology and engineering; Kemiteknik och kemisk teknologi;

    Sammanfattning : The Mg2+ and Mn2+ structures of calbindin D9k have been determined and they reveal a conformational change compared to the structures of apo and (Ca2+)2-calbindin D9k. These findings are unique, since normally calcium and not magnesium is known to induce conformational changes of EF-hand proteins. LÄS MER

  3. 22. Genetics in experimental traumatic brain injury

    Författare :Faiez Al Nimer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Traumatic brain injury (TBI) is the leading cause of death and disability in the young population in the industrialized world. It comprises a heterogeneous group of brain pathologies where head trauma initiates a series of complex molecular pathways, which, together with the initial injury, account for the final outcome. LÄS MER

  4. 23. Genetic regulation of nerve injury-induced neurodegeneration and inflammation

    Författare :Maria Swanberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Neurodegeneration and inflammation in the central nervous system (CNS) are hallmarks of several neurological disorders, including multiple sclerosis (MS), Alzheimer’s disease and Parkinson’s disease. The susceptibility of an individual to these conditions is complex, i.e. influenced by both genetic and environmental factors. LÄS MER

  5. 24. Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes

    Författare :Nádia Duarte; Dan Holmberg; David Serreze; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; type 1 diabetes; NOD mouse; susceptibility loci; Idd6; Lrmp; gene; NKT; CD1d; TCR; mast cells; Immunologi; Immunology; Immunologi; medicinsk genetik; Medical Genetics;

    Sammanfattning : Type 1 diabetes is an autoimmune disorder determined both by genetic and environmental factors. The Non-obese diabetic (NOD) mouse is one of the best animal models of this disease. It spontaneously develops diabetes through a process resembling the human pathogenesis. LÄS MER

  7. 25. The genetics of IgA deficiency : a ‛two-disease’ approach

    Författare :Ning Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Selective IgA deficiency (IgAD) is the most common primary immunodeficiency disorder in Caucasians with a prevalence of approximately 1:600 in the general population. It is defined as serum IgA levels below or equal to 0.07 g/l with normal serum levels of IgM and IgG above the age of 4. LÄS MER