Sökning: "MHC region"

Visar resultat 16 - 20 av 68 avhandlingar innehållade orden MHC region.

  1. 16. Genetic dissection of models for neuroinflammation and neurodegeneration

    Författare :Karin Harnesk; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Many central nervous system (CNS) diseases are characterized by inflammation and nerve cell loss, but the exact relationship between these phenomena is not known. The complex etiology of CNS disorders includes a genetic component. LÄS MER

  3. 17. Immunogenetics and treatment of experimental autoimmune encephalomyelitis

    Författare :Robert Weissert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multiple sclerosis; experimental autoimmune encephalomyelitis; major histocompatibility complex; myelin; myelin oligodendrocyte glycoprotein; T cell receptor;

    Sammanfattning : Experimental autoimmune encephalomyelities (EAE) is a model of multiple sclerosis (MS). This experimental central nervous system (CNS) disease can be induced in rats by immunization with components of the CNS myelin sheath. LÄS MER

  4. 18. Development and Application of Genomic Resources in Non-model Bird Species

    Författare :Biao Wang; Jacob Höglund; Christopher Wheat; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; genome; transcriptome; next generation sequencing; non-model species; bioinformatics; reference guided assembly; RNA-Seq; comparative genomics; gene expression; major histocompatibility complex; single nucleotide polymorphism; microsatellite; Biologi; Biology;

    Sammanfattning : Understanding the genetic basis of biological processes is a fundamental component of modern ecology and evolutionary biology studies. With the recent advent of next generation sequencing (NGS) technologies, it is now possible to perform large genome and transcriptome projects for ecologically important non-model species. LÄS MER

  5. 19. Equine trait mapping : from disease loci to the discovery of a major gene controlling vertebrate locomotion

    Författare :Lisa Andersson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Assigning function to genes is essential for a better understanding of biological systems. To date, approximately half of the genes in the vertebrate genome have known function. Domestic animals are a rich source for trait mapping and in this thesis we have mapped three distinct equine phenotypes. LÄS MER

  7. 20. Genetic regulation of neuroinflammation : a translational approach

    Författare :Johan Öckinger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS), causing demyelination and axonal damage. As other complex diseases with an inflammatory or autoimmune component, MHC is a strong regulator of the disease and acts in concert with multiple nonMHC genes and environmental factors. LÄS MER