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Visar resultat 1 - 5 av 68 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Evolution of MHC Genes and MHC Gene Expression

    Författare :Karin Berggren Bremdal; Hans Ellegren; Jennifer Seddon; Philip Hedrick; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; major histocompatibilty complex; dog leukocyte antigen; balancing selection; linkage disequilibrium; promoter; diabetes mellitus; Canis familiaris; Canis lupus; Erinaceus europaeus; Erinaceus concolor; Genetics; Genetik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik;

    Sammanfattning : Polymorphism in coding regions and regions controlling gene expression is the major determinant of adaptive differences in natural populations. Genes of the major histocompatibility complex (MHC) possess a high level of genetic variation, which is maintained by selection over long coalescence times. LÄS MER

  3. 2. MHC diversity and expression in a songbird : Temporal and transgenerational variation

    Författare :Samantha Mellinger; MEMEG; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MHC diversity; MHC-I gene expression; songbirds; genome assembly; amplicon HTS; temporal variation; family data; great reed warbler Acrocephalus arundinaceus ;

    Sammanfattning : The immune system is of central importance to clear-off pathogens in order to keep an organism healthy. In vertebrates, the Major Histocompatibility Complex (MHC) is a genomic region that holds key genes involved in adaptive immunity and in particular in the antigen presenting process. LÄS MER

  4. 3. Analysis of genetic susceptibility to cervical cancer using candidate gene and GWAS approaches

    Författare :Ivana Juko-Pecirep; Ulf Gyllensten; Holger Luthman; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cervical cancer; association study; human papillomavirus; genetics; complex disease; TMC6; TMC8; MHC region; Medical Genetics; Medicinsk genetik;

    Sammanfattning : Cervical cancer is the forth most commonly diagnosed cancer among women worldwide. It is caused by persistent infection with an oncogenic type of Human Papillomavirus (HPV). The HPV is a necessary but not sufficient cause of cervical cancer. LÄS MER

  5. 4. Immunological and Inflammtory Responses against Intrastriatal Neural Grafts in the Rat

    Författare :Wei-Ming Duan; Neurobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; MHC; Rat; Brain; Xenogeneic; Allogeneic; Syngeneic; Cytokine; Inflammation; Neural transplantation; Immunology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : Intracerebral neural transplantation offers a new strategy to combat Parkinson’s and Huntington’s diseases. However, a host immune response against a histoincompatible neural graft in the brain may jeopardize transplant survival. LÄS MER

  7. 5. Functional and genetic analyses of the MHC and its impact on autoimmunity in the rat

    Författare :Jonatan Tuncel; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The major histocompatibility complex (MHC) is an allele-rich and exceptionally gene dense region on human chromosome 6. Over 40% of the genes in this region have immune-related functions, including genes encoding MHCI and MHCII molecules. These molecules, which are found in nearly all vertebrates, present antigenic peptides to CD4 and CD8 T cells. LÄS MER