Sökning: "Linus Sandegren"

Visar resultat 6 - 10 av 10 avhandlingar innehållade orden Linus Sandegren.

1. 6. Selection of Resistance at very low Antibiotic Concentrations

   Författare :Erik Gullberg; Dan I Andersson; Diarmaid Hughes; Linus Sandegren; Laura Piddock; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Selection; Antibiotic resistant bacteria; Minimal inhibitory concentration; Heavy metals; Conjugative plasmid; ESBL; Mikrobiologi; Microbiology; Biology with specialization in Microbiology; Biologi med inriktning mot mikrobiologi; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

   Sammanfattning : The extensive medical and agricultural use and misuse of antibiotics during the last 70 years has caused an enrichment of resistant pathogenic bacteria that now severely threatens our capacity to efficiently treat bacterial infections. While is has been known for a long time that high concentrations of antibiotics can select for resistant mutants, less is known about the lower limit at which antibiotics can be selective and enrich for resistant bacteria. LÄS MER

3. 7. Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli

   Författare :Marius Linkevičius; Dan I. Andersson; Linus Sandegren; Patrice Courvalin; Uppsala universitet; []
   Nyckelord :Tigecycline; Bacterial resistance; Fitness; Escherichia coli; AcrAB; LPS; Tet proteins; Tet A ; Tet K ; Tet M ; Tet X ; tet genes; pUUH239.2; Mikrobiologi; Microbiology;

   Sammanfattning : Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging resistant pathogens. Tigecycline is one of few drugs that have been introduced into medicine during the last two decades. LÄS MER

4. 8. Exploring the interactions of antibiotic combinations against multidrug-resistant Gram-negative bacteria

   Författare :Anna Olsson; Thomas Tängdén; Linus Sandegren; Pernilla Lagerbäck; Joseph Meletiadis; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gram-negative bacteria combination therapy antimicrobial resistence; Medicinsk vetenskap; Medical Science;

   Sammanfattning : Antimicrobial resistance is emerging and available treatment options are lacking. Antibiotics is a cornerstone in modern medicine where medical procedures such as surgery, care of premature babies or treatment of cancer is dependent on efficient drugs. LÄS MER

5. 9. Multi-Resistance Plasmids : Fitness Costs, Dynamics and Evolution

   Författare :Fredrika Rajer; Linus Sandegren; Pål Jarle Johnsen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; multi-resistance plasmids; evolution; fitness cost; dynamics; escherichia coli; ESBL; gene amplification; β-lactamase inhibitor; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. LÄS MER

7. 10. Evolutionary trajectories of Klebsiella pneumoniae : From experimental biofilm evolution to a hospital outbreak

   Författare :Greta Zaborskytė; Linus Sandegren; Vaughn S. Cooper; Uppsala universitet; []
   Nyckelord :Klebsiella pneumoniae; evolution; experimental evolution; biofilms; infection; bacterial pathogens; Mikrobiologi; Microbiology;

   Sammanfattning : Bacterial evolution is closely intertwined with our lives. As their hosts, we shape how bacteria evolve by imposing numerous selective pressures during the time bacteria spend in our bodies. As a result, they adapt in various ways to colonize us or infect us better. LÄS MER