Sökning: "AcrAB"

Hittade 4 avhandlingar innehållade ordet AcrAB.

  1. 1. Evolution and Mechanisms of Tigecycline Resistance in Escherichia coli

    Författare :Marius Linkevičius; Dan I. Andersson; Linus Sandegren; Patrice Courvalin; Uppsala universitet; []
    Nyckelord :Tigecycline; Bacterial resistance; Fitness; Escherichia coli; AcrAB; LPS; Tet proteins; Tet A ; Tet K ; Tet M ; Tet X ; tet genes; pUUH239.2; Mikrobiologi; Microbiology;

    Sammanfattning : Antibiotic resistance is an ongoing global medical crisis and we are in great need of new antibacterial agents to combat rapidly emerging resistant pathogens. Tigecycline is one of few drugs that have been introduced into medicine during the last two decades. LÄS MER

  3. 2. Antibiotic resistance in Gram-negative bacilli : with focus on cephalosporin resistance mechanisms in Escherichia coli and Klebsiella pneumoniae

    Författare :Owe Källman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Objectives: The objectives of this thesis were to study mechanisms conferring cefuroxime resistance in clinical non-ESBL (extended-spectrum beta-lactamase) producing isolates of Escherichia coli and Klebsiella pneumoniae, as well as the presence of co-resistance to other antibiotics in the K. pneumoniae isolates. LÄS MER

  4. 3. Constraints on up-regulation of drug efflux in the evolution of ciprofloxacin resistance

    Författare :Lisa Praski Alzrigat; Diarmaid Hughes; Fernando Baquero; Uppsala universitet; []
    Nyckelord :ciprofloxacin; antibiotic resistance; drug efflux; bacterial fitness; marR; acrR; marA; experimental evolution; Mikrobiologi; Microbiology;

    Sammanfattning : The crucial role of antibiotics in modern medicine, in curing infections and enabling advanced medical procedures, is being threatened by the increasing frequency of resistant bacteria. Better understanding of the forces selecting resistance mutations could help develop strategies to optimize the use of antibiotics and slow the spread of resistance. LÄS MER

  5. 4. Borrelia channel-forming proteins : structure and function

    Författare :Ignas Bunikis; Sven Bergström; Steven Norris; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Borrelia; Lume disease; relapsing fever; BesC; drug efflux; DipA; P66; porins; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Borrelia is a Gram-negative, corkscrew-shaped bacterium transmitted by infected ticks or lice. Borreliae are subdivided into pathogens of two diseases: Lyme disease, caused mainly by B. burgdorferi, B. afzelii and B. LÄS MER