Sökning: "β-lactamase inhibitor"
Hittade 5 avhandlingar innehållade orden β-lactamase inhibitor.
1. Development of phosphorus-containing metallo-β-lactamase inhibitors : Synthesis and binding studies by solution NMR and molecular docking
Sammanfattning : The rapidly growing bacterial resistance development is turning into one of the main challenges of the 21st century. Our antibiotics are becoming ineffective for the treatment of bacterial infections, and without successful action, simple infections, such as pneumonia or Septicemia, will soon carry a highly probable mortal prognosis. LÄS MER
2. Multi-Resistance Plasmids : Fitness Costs, Dynamics and Evolution
Sammanfattning : Antibiotic resistance is an escalating problem, not only due to less desirable treatment options and outcome, but also due to the economic burden to health care caused by resistant pathogens. Since the process of developing new antibiotics is slow, we need to carefully consider the usage of the antibiotics still available. LÄS MER
3. β-lactam combinations against multidrug-resistant Enterobacterales : Exploring combination effects and resistance development
Sammanfattning : The β-lactam antibiotics are a cornerstone in treating bacterial infections, but the increasing prevalence of antibiotic resistance worldwide threatens their effectiveness. The main driver of β-lactam resistance is the production of β-lactamases, which are bacterial enzymes that inactivate the antibiotic. LÄS MER
4. Advanced NMR techniques for structural elucidation in medicinal chemistry
Sammanfattning : The nuclear Overhauser effect (NOE) is an NMR phenomenon that can reveal spatial proximity between two atoms. It has found applications in organic chemistry and structural biology including natural product chemistry, organic synthesis, medicinal chemistry, macromolecular structure elucidation and protein-ligand interactions. LÄS MER
5. Extremely drug resistant E. coli and K. pneumoniae : novel approaches against their spread and related infections
Sammanfattning : Antibiotic resistance in Enterobacteriaceae is a well-established hindrance and the spread of pathogenic high-risk clones harboring extended-spectrum -lactamases (ESBLs) and carbapenemases is posing a global health challenge, due to very less treatment alternatives. Particular lineages from the major representative species E. coli and K. LÄS MER