Sökning: "Linus Sandegren"

Visar resultat 1 - 5 av 9 avhandlingar innehållade orden Linus Sandegren.

1. 1. Group I Introns and Homing Endonucleases in T-even-like Bacteriophages

   Författare :Linus Sandegren; Britt-Marie Sjöberg; Renée Schroeder; Stockholms universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Bacteriophage; Self-splicing introns; Homing endonucleases; Molecular biology; Molekylärbiologi;

   Sammanfattning : Homing endonucleases are rare-cutting enzymes that cleave DNA at a site near their own location, preferentially in alleles lacking the homing endonuclease gene (HEG). By cleaving HEG-less alleles the homing endonuclease can mediate the transfer of its own gene to the cleaved site via a process called homing, involving double strand break repair. LÄS MER

3. 2. Mechanisms and Dynamics of Carbapenem Resistance in Escherichia coli

   Författare :Marlen Adler; Linus Sandegren; Josep Casadesús; Uppsala universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; carbapenem; antibiotic resistance; fitness cost; ESBLs; penicillin-binding proteins; gene amplification;

   Sammanfattning : The emergence of extended spectrum β-lactamase (ESBL) producing Enterobacteriaceae worldwide has led to an increased use of carbapenems and may drive the development of carbapenem resistance. Existing mechanisms are mainly due to acquired carbapenemases or the combination of ESBL-production and reduced outer membrane permeability. LÄS MER

4. 3. Long-term molecular epidemiology of extended-spectrum β-lactamase producing Escherichia coli in a low-endemic setting

   Författare :Anna Fagerström; Bo Söderquist; Paula Mölling; Martin Sundqvist; Katarina Persson; Linus Sandegren; Örebro universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Escherichia coli; extended-spectrum β-lactamase; whole genome sequencing; plasmids; hybrid assembly; environment; IncI1; ST131;

   Sammanfattning : Escherichia coli is a commensal inhabitant in the gastro-intestinal tract of humans and animals but it is also the most common bacterial species causing urinary tract infection, which ranges in severity from distal cystitis to urosepsis and septic shock. During the past decades, the prevalence of antibiotic resistant E. LÄS MER

5. 4. A Unified Multitude : Experimental Studies of Bacterial Chromosome Organization

   Författare :Eva Garmendia; Diarmaid Hughes; Linus Sandegren; John R. Roth; Uppsala universitet; []
   Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; bacterial evolution; chromosome organization and structure; chromosomal inversions; EF-Tu; horizontal gene transfer; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology;

   Sammanfattning : Bacteria are many, old and varied; different bacterial species have been evolving for millions of years and show many disparate life-styles and types of metabolism. Nevertheless, some of the characteristics regarding how bacteria organize their chromosomes are relatively conserved, suggesting that they might be both ancient and important, and that selective pressures inhibit their modification. LÄS MER

7. 5. Selection of Resistance at very low Antibiotic Concentrations

   Författare :Erik Gullberg; Dan I Andersson; Diarmaid Hughes; Linus Sandegren; Laura Piddock; Uppsala universitet; []
   Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Antibiotic resistance; Selection; Antibiotic resistant bacteria; Minimal inhibitory concentration; Heavy metals; Conjugative plasmid; ESBL; Mikrobiologi; Microbiology; Biology with specialization in Microbiology; Biologi med inriktning mot mikrobiologi; Biology with specialization in Molecular Evolution; Biologi med inriktning mot molekylär evolution;

   Sammanfattning : The extensive medical and agricultural use and misuse of antibiotics during the last 70 years has caused an enrichment of resistant pathogenic bacteria that now severely threatens our capacity to efficiently treat bacterial infections. While is has been known for a long time that high concentrations of antibiotics can select for resistant mutants, less is known about the lower limit at which antibiotics can be selective and enrich for resistant bacteria. LÄS MER