Sökning: "LTD4"

Visar resultat 11 - 15 av 36 avhandlingar innehållade ordet LTD4.

  1. 11. Eicosanoids and exosomes : a link between macrophages and lung cancer

    Författare :Ana Lukic; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic inflammation increases the risk of lung cancer. Macrophages (MO) are important players in inflammation, with regulatory and executive functions. Eicosanoids and exosomes can be both triggers and mediators of these functions. LÄS MER

  3. 12. The role of CysLT1R in animal models of colorectal cancer

    Författare :Sayeh Savari; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. LÄS MER

  4. 13. Leukotriene D4-induced signal transduction in human epithelial cells

    Författare :Eva Grönroos; Else Kay Hoffmann; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Although the structures of the cysteinyl-leukotrienes have been known for almost twenty years, and their biological effects for almost sixty years, very little is known about the signaling propenies of these compounds. The aim of the present research was to further elucidate the components that are involved in the signaling mechanisms of leukotriene D4 (L TD4) in a human epithelial cell line. LÄS MER

  5. 14. Crosstalk between colorectal cancer cells and tumour-associated macrophages

    Författare :Yuan Zhang; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; tumour-associated macrophage; matrix metalloproteinase; cell migration; colon cancer;

    Sammanfattning : Colorectal cancer (CRC) is the third most common cancer and the fourth leading cause of death from cancer worldwide. People suffering from inflammatory bowel disease, such as Crohns’ disease and ulcerative colitis, are at an increased risk of developing CRC. The development of CRC is highly influenced by the tumour microenvironment. LÄS MER

  7. 15. Anti-Tumor Effects of CysLT2R in Epithelial Cancer

    Författare :Cecilia Magnusson; Malmö Cellpatologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; migration; Colon cancer; breast cancer; EGF; interferon;

    Sammanfattning : The pro-inflammatory cysteinyl leukotrienes (cysLTs) are implicated in several pathological disorders, such as asthma and inflammatory diseases. The well-established connection between chronic inflammation and cancer implicates inflammatory mediators in cancer progression. It is therefore of interest to examine the effects of the CysLTs in cancer. LÄS MER