Sökning: "LIRA"

Hittade 4 avhandlingar innehållade ordet LIRA.

  1. 1. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

    Författare :Jorge Lira Ruas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

    Sammanfattning : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. LÄS MER

  3. 2. Gradation-Based Framework for Asphalt Mixtures

    Författare :Bernardita Francisca Lira Miranda; Björn Birgisson; Terhi Pellinen; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Asphalt; aggregate gradation; packing theory; asphalt microstructure; porosity; film thickness; rutting; moisture damage.; SRA - Transport; SRA - Transport;

    Sammanfattning : Asphalt mixture microstructure is formed by aggregates, bitumen binder and air voids. Aggregates make for up to 90% of the mixtures volume and the structure formed by them will depend mostly on their size distribution and shape. LÄS MER

  4. 3. Influence of aggregates on permanent deformation of asphalt

    Författare :Bernardita Francisca Lira Miranda; Robert Lundström; Stefan Larsson; Alan Carter; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Asphalt; deformation; rutting; gradation; flakiness index; Asfalt; kornstorleksfördelning; flisighetsindex; permanent deformation; spårbildning.; Jord- och bergmekanik; Soil and Rock Mechanics;

    Sammanfattning : One of the most common failure modes for asphalt pavements is the occurrence of permanent deformation on the wheel path. This leads to not only other distresses, such as potholes and stripping, but also decreases substantially road safety and increases maintenance costs. LÄS MER

  5. 4. Long-term Performance of PVC and CSPE Cables used in Nuclear Power Plants : the Effect of Degradation and Plasticizer migration

    Författare :Maria Ekelund; Ulf Gedde; Thomas Hjertberg; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; PCV; CSPE; cables; ageing; mechanical properties; plasticizer migratio; LIRA; life time prediction; Chemistry; Kemi;

    Sammanfattning : Enormous amounts of low voltage cables installed in a Swedish nuclear power plant are reaching their expected lifetimes. Since the cables are crucial to operational safety, it is of great importance that the actual condition of the installed cables is determined. LÄS MER