Sökning: "Jorge Lira Ruas"

Hittade 1 avhandling innehållade orden Jorge Lira Ruas.

  1. 1. Oxygen-dependent regulation of transcription by the hypoxia-inducible factor-1

    Författare :Jorge Lira Ruas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Hypoxia; HIF-1; protein degradation; transcription; coactivators; CBP; subcellular localization; C1-tetrahydrofolate synthase;

    Sammanfattning : Under limited oxygen availability (hypoxia) cells undergo rapid reprogramming in order to survive in the new environment until normoxic conditions are re-established. The observation that hypoxia can induce the expression of genes involved in erythropoiesis, angiogenesis and glucose metabolism among others, led to the identification of the hypoxia-inducible factor-1 (HIF-1) as a master regulator of the hypoxia-response pathway. LÄS MER