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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Mechanisms of immune escape : implications for immunotherapy against cancer

    Författare :Karl-Johan Malmberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Tumor Immunology; Immune escape; NK receptors; T lymphocytes; Oxidative stress; Vitamin E;

    Sammanfattning : Tumor cells can be recognized and killed by cytotoxic T cells specific for certain tumor antigens. Immune mediated selection pressure along with genetic instability of tumor cells result in a growth advantage of tumor cells that acquire a less immunogenic phenotype. LÄS MER

  3. 2. CD19-targeting CAR T Cells for Treatment of B Cell Malignancies : From Bench to Bedside

    Författare :Hannah Karlsson; Angelica Loskog; Karl-Johan Malmberg; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; chimeric antigen receptors; CAR T cells; T cell therapy; immunotherapy; CD19; Bcl-2 family inhibitors; B cell malignancies; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Immunotherapy for cancer is a young research field progressing at high speed. The first chimera of an antibody and a signaling chain was designed by Zelig Eshhar and was later further developed to enhance existing T cell therapy by combining a single-chain fragment of an antibody with the CD3 zeta chain of the TCR complex. LÄS MER

  4. 3. Kunskap och innovation i ett moget kluster : En ekonomisk-geografisk studie av aluminiumindustrin i Småland-Blekinge

    Författare :Magnus Lagerholm; Anders Malmberg; Anders Waxell; Karl-Johan Lundquist; Uppsala universitet; []
    Nyckelord :Social and economic geography; economic geography; mature industry; cluster; agglomeration; systems of innovation; labour market mobility; Sweden; Kulturgeografi; kulturgeografi; Social and Economic Geography;

    Sammanfattning : The thesis aims at understanding mechanisms behind knowledge generation and learning in a mature cluster by analysing firms in south-east Sweden engaged in the development and manufacturing of aluminium products. The point of departure is in concepts and assumptions related to spatially concen-trated systems of similar and related firms and industries, such as agglomera-tions, clusters or innovation systems. LÄS MER

  5. 4. Cancer Immunotherapy : Oncolytic viruses and CAR-T cells

    Författare :Jing Ma; Di Yu; Magnus Essand; Mia Phillipson; Mohanraj Ramachandran; Karl-Johan Malmberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer immunotherapy; Oncolytic viruses; chimeric antigen receptor CAR -T cells; Helicobacter pylori Neutrophil Activating Protein;

    Sammanfattning : Various forms of cancer immunotherapy have developed rapidly with improved survival and quality of life for cancer patients. Cancer immunotherapy aims to educate the patient’s immune system to eliminate cancer cells, including immune checkpoint inhibitors (ICIs), adoptive cell transfer (mostly T cells), oncolytic viruses (OVs) and cancer vaccines. LÄS MER

  7. 5. Adoptive T Cell Therapy for Treatment of Metastatic Melanoma

    Författare :Arian Sadeghi; Thomas Tötterman; Karl-Johan Malmberg; Uppsala universitet; []
    Nyckelord :Malignant melanoma; Adoptive cell therapy; MEDICINE; MEDICIN;

    Sammanfattning : Malignant melanoma is a common type of solid tumor that causes high cancer-related mortality in young adults of Northern Europe. The incidence of melanoma increases rapidly which renders us a special responsibility to investigate this disease in depth. LÄS MER