Sökning: "Adoptive cell therapy"

Visar resultat 1 - 5 av 29 avhandlingar innehållade orden Adoptive cell therapy.

  1. 1. Adoptive T Cell Therapy of Viral Infection and Cancer : Ex vivo Expansion of Cytomegalovirus- and Prostate Antigen-specific T Cells

    Författare :Björn Carlsson; Magnus Essand; Thomas Tötterman; Malcolm Brenner; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Immunotherapy; Adoptive T cell therapy; Dendritic cell; T cell; Tetramer; Cytomegalovirus; Transplantation; pp65; Prostate cancer; TARP; Prostate antigens; Immunologi; Immunology; Immunologi;

    Sammanfattning : The main focus of my thesis has been to develop protocols for generating antigen-specific cytotoxic T lymphocytes (CTLs) and T helper cells (TH) for adoptive transfer to treat cytomegalovirus (CMV) disease and prostate cancer. CMV viremia is a severe complication in immunocompromised stem cell transplanted patients. LÄS MER

  3. 2. Adoptive T Cell Therapy for Treatment of Metastatic Melanoma

    Författare :Arian Sadeghi; Thomas Tötterman; Karl-Johan Malmberg; Uppsala universitet; []
    Nyckelord :Malignant melanoma; Adoptive cell therapy; MEDICINE; MEDICIN;

    Sammanfattning : Malignant melanoma is a common type of solid tumor that causes high cancer-related mortality in young adults of Northern Europe. The incidence of melanoma increases rapidly which renders us a special responsibility to investigate this disease in depth. LÄS MER

  4. 3. Improvement of adoptive T-cell therapy for Cancer

    Författare :Chuan Jin; Magnus Essand; Ola Winqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAR T-cell therapy; AEP expansion protocol; scaffold matrix attachment region; non-integrating lentivirus; H. pylori Neutrophil-activating protein; allogeneic DCs; Klinisk immunologi; Clinical Immunology;

    Sammanfattning : Cancer immunotherapy has recently made remarkable clinical progress. Adoptive transfer of T-cells engineered with a chimeric antigen receptor (CAR) against CD19 has been successful in treatment of B-cell leukemia. LÄS MER

  5. 4. Evaluating antitumoral lymphocytes for adoptive cell therapy : oxidative stress, neoantigen processing and co-stimulation

    Författare :Stefanie Marie Renken; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Rapid advancement in the field of immunotherapy has changed the treatment landscape of cancer, especially with the approval of immune checkpoint inhibitors for a wide range of cancer types. However, a large proportion of patients does not benefit from this treatment. LÄS MER

  7. 5. Single Cell Investigations of the Functional Heterogeneity Within Immune Cell Populations : a Microchip-based Study

    Författare :Karolin Guldevall; Björn Önfelt; Hjalmar Brismar; Carsten Watzl; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Biologisk fysik; Biological Physics;

    Sammanfattning : Immune cell populations are constantly divided into smaller and smaller subsets defined by newly emerging cellular markers. However, there is a growing awareness of the functional heterogeneities in between cells even within small populations, in addition to the heterogeneity over time. LÄS MER