Sökning: "Immune microenvironment"

Visar resultat 6 - 10 av 143 avhandlingar innehållade orden Immune microenvironment.

1. 6. Improving the diagnostic armamentarium of lung cancer

   Författare :Hedvig Elfving; Patrick Micke; Fredrik Pontén; Marika Nestor; Reinhard Büttner; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lung cancer; tissue microarray; immunohistochemistry; targeted therapy; immunotherapy; checkpoint inhibitors; immune microenvironment; prognosis; biomarkers; immune cells.;

   Sammanfattning : Lung cancer is the leading cause of cancer-related death globally, with non-small cell lung cancer (NSCLC) constituting 85% of cases. The introduction of immunotherapies and targeted therapies have dramatically improved the prognosis and outcome for a subset of patients, and stressed the development of diagnostic tools for effective patient selection. LÄS MER

3. 7. Immunologic Markers in the Tumor Microenvironment of Classical Hodgkin Lymphoma

   Författare :Alex R. Gholiha; Gunilla Enblad; Rose-Marie Amini; Peter Hollander; Gustaf Hedström; Arjan Diepstra; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tumor microenvironment; immunohistochemistry; immune checkpoints; Plasma cells; IL-6 cytokine; Proteomics; CD47.;

   Sammanfattning : In classical Hodgkin lymphoma (cHL), cytokine regulation and cellular composition of the tumor microenvironment (TME) is crucial for tumor cell survival. In paper I, we examined the presence of CD138+ plasma cells and IgG4+ plasma cells in diagnostic cHL biopsies with immunohistochemistry (IHC). LÄS MER

4. 8. Molecular Investigations of high-risk Mantle Cell Lymphoma : Genetic factors and the impact of the microenvironment

   Författare :Joana de Matos Rodrigues; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; CPT1A; TP53; c-Myc; Immune microenvironment; Macrophages;

   Sammanfattning : Mantle cell lymphoma (MCL) is an aggressive disease, with variable clinical course and heterogenous molecular characteristics. In this thesis, which is based upon six original papers, we aimed to understand MCL deregulations, both at intrinsic and extrinsic levels, to identify companion biomarkers that would allow patient stratification. LÄS MER

5. 9. The immune microenvironment in mantle cell lymphoma : Targeted liquid and spatial proteomic analyses

   Författare :Lavanya Lokhande; Institutionen för immunteknologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; proteomic analyses; spatial analysis; Biomarker discovery; immune microenviroment; serum proteomics;

   Sammanfattning : The complex interplay of the tumour and immune cells affects tumour growth, progression, and response to treatment. Restorationof effective immune response forms the basis of onco-immunology, which further enabled the development of immunotherapy. LÄS MER

7. 10. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

   Författare :Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

   Sammanfattning : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. LÄS MER