Sökning: "c-Myc"

Visar resultat 1 - 5 av 83 avhandlingar innehållade ordet c-Myc.

  1. 1. Modulating the activity of the c-Myc oncoprotein

    Författare :Per Hydbring; Sveriges lantbruksuniversitet.; [2009]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The Myc oncoprotein regulates numerous cellular processes and is frequently deregulated in cancer due to genetic lesions. However, in addition to its tumor promoting activity, Myc and other oncoproteins induce intrinsic safe-guard mechanisms against tumorigenesis like apoptosis and cellular senescence, which have to be overcome by additional genetic lesions for cellular transformation. LÄS MER

  2. 2. Regulation of the ribosomal RNA transcription by c-MYC oncoprotein

    Detta är en avhandling från Stockholm : Karolinska Institutet, Biosciences and Nutrition

    Författare :Azadeh Arabi; Karolinska Institutet.; Karolinska Institutet.; Södertörns högskola.; [2006]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Myc; Nucleolus; Proteasome; RNA Polymerase; Cancer;

    Sammanfattning : The transcription factor c-Myc is a key regulator of growth and proliferation. c-Myc levels are tightly controlled and deregulated c-Myc is often associated with human cancers. In our initial studies we observed that upon inhibition of proteasomes, excess c-Myc accumulates primarily in the nucleoli. LÄS MER

  3. 3. Structural biology of transcriptional regulation in the c-Myc network

    Detta är en avhandling från Linköping : Linköping University Electronic Press

    Författare :Sara Helander; Linköpings universitet.; Linköpings universitet.; [2014]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The oncogene c-­‐Myc is overexpressed in many types of human cancers and regulation of c-­‐Myc expression is crucial in a normal cell. The intrinsically disordered N-­‐terminal transactivation domain interacts with a wide range of proteins regulating c-­‐Myc activity. LÄS MER

  4. 4. Studies on the antiproliferative action of interferon effects on proteins synthesized in the G1 and S phase of the cell cycle in 2 anchorage-dependent cell lines

    Detta är en avhandling från Umeå : Umeå universitet

    Författare :Dan Lundblad; Umeå universitet.; [1991]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Interferon; Glioma; Antiproliferative effect; DNA polymerase; Thymidine kinase; 2 -5 oligo A; Protein synthesis; Two-dimensional electrophorensis; Mouse fibroblasts; C-myc; KI-67 antigen;

    Sammanfattning : Interferons (IFNs) are a class of structurally related proteins first discovered to be produced by virus-infected cells. By now, several other inducing agents have been described. LÄS MER

  5. 5. Mechanisms of HAMLET-induced cancer cell death

    Detta är en avhandling från Division of Microbiology, Immunology and Glycobiology - MIG

    Författare :Sonja Aits; Lund University.; Lunds universitet.; [2010]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-actinin; prohibitin; alpha-lactalbumin; HAMLET; cancer; cell death; autophagy; focal adhesions; c-Myc; hexokinase; glycolysis;

    Sammanfattning : HAMLET, a complex of α-lactalbumin and oleic acid, preferentially kills cancer cells and is also effective in vivo. HAMLET causes apoptosis but cells die even if this pathway is inhibited. Thus, the role of autophagy, an alternative cell death pathway, was examined. LÄS MER