Sökning: "Hydrophilic matrices"

Visar resultat 1 - 5 av 19 avhandlingar innehållade orden Hydrophilic matrices.

  1. 1. Mechanistic Modelling of Drug Dissolution and Matrix Formulations: Rotating Disc Dissolution, Dissolution in a Stagnant Medium, Swelling and Dissolving Matrix Systems

    Författare :Erik Kaunisto; Avdelningen för kemiteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Rotating Disc; Diffusion; Dissolution; Controlled Release; Hydrophilic matrices; ESPI;

    Sammanfattning : Popular Abstract in Swedish Under årens lopp har människan gjort stora landvinningar inom läkemedelsforskning, vilket har lett fram till avancerade läkemedel som idag tas för givna. Avancerade läkemedel sätter dock höga krav på tillverkarna av läkemedel, vilket har lett till att framtagandet av nya läkemedel är en ganska komplicerad process. LÄS MER

  3. 2. Swelling of Cellulose Fibrillar Matrices and Gels

    Författare :Pernilla Karlsson; Lars Wågberg; Per Tomas Larsson; Eero Kontturi; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; swelling; hydrogel; cellulose; wood; cellulose fibrils; Fiber- och polymervetenskap; Fibre and Polymer Science;

    Sammanfattning : One of the major challenges of today´s society is to find a sustainable way to create a living based on the resources on earth. It is a challenge that includes a transition from fossil-based materials to renewable/biodegradable raw materials and also the creation of an environmentally friendly circular material flow. LÄS MER

  4. 3. Development of LC-MS/MS Methods for the Analysis of Chiral and Achiral Pharmaceuticals and Metabolites in Aqueous Environmental Matrices

    Författare :Victoria K.H. Barclay; Curt Pettersson; Monika Johansson; Niklas Tyrefors; Mohamed Abdel-Rehim; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Environmental water matrices; chiral separation; LC-MS MS; trace analysis; method development; active pharmaceutical ingredients; metabolites; Analytical Pharmaceutical Chemistry; Analytisk farmaceutisk kemi;

    Sammanfattning : This thesis describes the development of liquid chromatography tandem mass spectrometry (LC-MS/MS) methods for the trace analysis of active pharmaceutical ingredients (APIs) and their metabolites in aqueous environmental matrices. The research was focused on the development of chiral LC-MS/MS methods for the analysis of fluoxetine and metoprolol, as well as their chiral metabolites in environmental water samples. LÄS MER

  5. 4. Investigation of the functionality related characteristics of hydroxypropyl methylcellulose for the release from matrix tablets

    Författare :Anna Viridén; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; functionality related characteristics; batch-to-batch variation; hydrophilic matrix tablets; hydroxypropyl methylcellulose; polymer characterisation; heterogeneous; drug release;

    Sammanfattning : Hydrophilic matrix tablets are a compressed well mixed composite of drug substance and excipients including a hydrophilic polymer. When the tablet comes in contact with biological fluids, the hydrophilic polymer starts to dissolve, a process that decreases the water penetration through the tablet and involves dimensional changes of the tablet due to swelling of the solvated polymers. LÄS MER

  7. 5. Antioxidants in Andean food and meals

    Författare :Leslie Tejeda; Livsmedelsteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Antioxidant capacity; polyphenolic compounds; anthocyanidins; individual food; meals; ans and stan genes;

    Sammanfattning : Abstract The constant need to improve health and to prevent disease in Bolivia, especially in the Andean region with its extreme environmental conditions (high altitude and lower temperatures), motivated us to extend studies of antioxidant sources in foods and plants, since antioxidants are believed to have major health benefits. Spectrophotometric methods, such as ABTS (2, 2’- azinobis-3-ethylbenzotiazoline-6-sulfonic acid) and FRAP (ferric reduction antioxidant power), were used to evaluate antioxidant activity. LÄS MER