Sökning: "batch-to-batch variation"

Hittade 4 avhandlingar innehållade orden batch-to-batch variation.

  1. 1. Investigation of the functionality related characteristics of hydroxypropyl methylcellulose for the release from matrix tablets

    Författare :Anna Viridén; Chalmers tekniska högskola; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; functionality related characteristics; batch-to-batch variation; hydrophilic matrix tablets; hydroxypropyl methylcellulose; polymer characterisation; heterogeneous; drug release;

    Sammanfattning : Hydrophilic matrix tablets are a compressed well mixed composite of drug substance and excipients including a hydrophilic polymer. When the tablet comes in contact with biological fluids, the hydrophilic polymer starts to dissolve, a process that decreases the water penetration through the tablet and involves dimensional changes of the tablet due to swelling of the solvated polymers. LÄS MER

  3. 2. Use of Recombinant Allergens for Component-Resolved Diagnostics (CRD) in IgE-Mediated Allergy

    Författare :Åsa Marknell DeWitt; Pia Ek; Jonas Lidholm; Ronald van Ree; Uppsala universitet; []
    Nyckelord :Biomedical laboratory science; recombinant allergen; IgE; component-resolved diagnostics; CRD; tropomyosin; Phl p 11; Phl p 4; Pen a 1; Hev b 5; Biomedicinsk laboratorievetenskap;

    Sammanfattning : Immunoglobulin E (IgE)-mediated allergy occurs when our immune system causes a reaction to otherwise harmless substances (allergens). Allergens are predominantly proteins present in biological materials such as pollens, mites, animal epithelia, moulds and foods. LÄS MER

  4. 3. Welding of Ti-6Al-4V: Influence of welding process and alloy composition on microstructure and properties

    Författare :Sakari Tolvanen; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; fatigue; microstructure; Ti-6Al-4V; porosity; welding; defects;

    Sammanfattning : Titanium alloys are widely used for components in the fan and compressor sections of aeroengines mainly because of their superior strength-to-weight ratio. Large static compressor components can be manufactured by welding together smaller subcomponents, which has potential to provide benefits such as higher buy-to-fly ratio and improved performance of the components. LÄS MER

  5. 4. Natural killer cells, multiple myeloma, and daratumumab : a love-hate relationship

    Författare :Michael Chrobok; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Multiple myeloma is a treatable, but not yet curable, malignant plasma cell disease. Over the last decades, the overall survival time of multiple myeloma patients has constantly increased thanks to improvements in conventional treatment methods like chemotherapy as well as autologous stem cell transplantation both in combination with novel drugs such as proteasome inhibitors or immunomodulatory drugs. LÄS MER