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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Etiology of oral cancer

    Författare :Elsy-Britt Schildt; Mikael Eriksson; Lennart Hardell; Gunnar Steineck; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oral cancer; case-control study; snuff use; smoking; alcohol; HSV-infections; dental factors; occupations; molecular epidemiology; p53;

    Sammanfattning : .... LÄS MER

  3. 2. The use of peptides for studying molecular events in HIV- and HSV-infections

    Författare :Michael Levi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Synthetic peptides were used as tools in order to study various characteristic sof human immunodeficiency virus (HIV) and herpes simplex virus (HSV). Peptides were designed as multiple antigenic peptides (MAPs) and used as HIV vaccines in experimental animals. The included HIV epitopes were more immunogenic when immunized as MAPs than as a protein. LÄS MER

  4. 3. Interaction of herpes simplex virus with cell surface glycosaminoglycans as a target for antiviral intervention

    Författare :Kicki Bergefall; Göteborgs universitet; []
    Nyckelord :HSV; glycoproteins; glycosaminoglycans; virus receptor; antiviral drugs;

    Sammanfattning : Herpes simplex virus (HSV) infections in humans are predominantly manifested as oral cold sores or genital ulcers. As HSV infects cells by interaction with cell surface heparan sulfate (HS) and/or chondroitin sulfate (CS), the aim of the research work presented in this thesis was to explore the possibility of antiviral intervention with compounds that mimic HS or CS. LÄS MER

  5. 4. Anti-herpes simplex virus activities of sulfomannan oligosaccharide PI-88 and disulfated cyclitols

    Författare :Maria Ekblad; Göteborgs universitet; []
    Nyckelord :herpes simplex virus; antiviral drugs; viral glycoproteins; heparan sulfate mimetic; PI-88;

    Sammanfattning : Herpes simplex virus (HSV) initiates invasion of human cells by binding to the cell surface heparan sulfate (HS) glycosaminoglycan chains. This step is mediated by the viral envelope glycoproteins gC and/or gB. LÄS MER

  7. 5. The discovery of antiviral compounds targeting adenovirus and herpes simplex virus : assessment of synthetic compounds and natural products

    Författare :Mårten Strand; Göran Wadell; Mikael Elofsson; Ya-Fang Mei; Lieve Naesens; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; virology; antiviral; adenovirus; herpes simplex virus; small molecule; inhibitor; hsv; drug discovery; medicinsk virologi; Medical Virology; datorlingvistik; computational linguistics; mikrobiologi; Microbiology;

    Sammanfattning : There is a need for new antiviral drugs. Especially for the treatment of adenovirus infections, since no approved anti-adenoviral drugs are available. Adenovirus infections in healthy persons are most often associated with respiratory disease, diarrhea and infections of the eye. These infections can be severe, but are most often self-limiting. LÄS MER