Sökning: "PI-88"

Hittade 2 avhandlingar innehållade ordet PI-88.

1. 1. Anti-herpes simplex virus activities of sulfomannan oligosaccharide PI-88 and disulfated cyclitols

   Författare :Maria Ekblad; Göteborgs universitet; []
   Nyckelord :herpes simplex virus; antiviral drugs; viral glycoproteins; heparan sulfate mimetic; PI-88;

   Sammanfattning : Herpes simplex virus (HSV) initiates invasion of human cells by binding to the cell surface heparan sulfate (HS) glycosaminoglycan chains. This step is mediated by the viral envelope glycoproteins gC and/or gB. LÄS MER

3. 2. Interaction of herpes simplex virus with cell surface glycosaminoglycans as a target for antiviral intervention

   Författare :Kicki Bergefall; Göteborgs universitet; []
   Nyckelord :HSV; glycoproteins; glycosaminoglycans; virus receptor; antiviral drugs;

   Sammanfattning : Herpes simplex virus (HSV) infections in humans are predominantly manifested as oral cold sores or genital ulcers. As HSV infects cells by interaction with cell surface heparan sulfate (HS) and/or chondroitin sulfate (CS), the aim of the research work presented in this thesis was to explore the possibility of antiviral intervention with compounds that mimic HS or CS. LÄS MER