Sökning: "Design of Experiments DoE"

Visar resultat 1 - 5 av 21 avhandlingar innehållade orden Design of Experiments DoE.

  1. 1. Contributions to the Use of Statistical Methods for Improving Continuous Production

    Författare :Francesca Capaci; Erik Vanhatalo; Bergquist Bjarne; Murat Kulahci; Johan Carlson; Luleå tekniska universitet; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; Process industry; Continuous process; Statistical process control; Design of experiments; Process improvements; Simulation tool; Engineering process control; Kvalitetsteknik; Quality Technology and Management;

    Sammanfattning : Complexity of production processes, high computing capabilities, and massive datasets characterize today’s manufacturing environments, such as those of continuous andbatch production industries. Continuous production has spread gradually acrossdifferent industries, covering a significant part of today’s production. LÄS MER

  2. 2. Multivariate design of molecular docking experiments : An investigation of protein-ligand interactions

    Författare :David Andersson; Anna Linusson Jonsson; Gabriele Cruciani; Umeå universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular docking; chemometrics; multivariate analysis; principal component analysis; PCA; design of experiments; DoE; partial least-square projections to latent structures; PLS; scoring functions; ligand-binding cavity; major histocompatibility complex; MHC; glycopeptide; T-cell.; Pharmaceutical chemistry; Läkemedelskemi; datorlingvistik; computational linguistics;

    Sammanfattning : To be able to make informed descicions regarding the research of new drug molecules (ligands), it is crucial to have access to information regarding the chemical interaction between the drug and its biological target (protein). Computer-based methods have a given role in drug research today and, by using methods such as molecular docking, it is possible to investigate the way in which ligands and proteins interact. LÄS MER

  3. 3. Contributions to the use of designed experiments in continuous processes : a study of blast furnace experiments

    Författare :Erik Vanhatalo; Luleå tekniska universitet; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kvalitetsteknik; Quality Technology Management;

    Sammanfattning : Design of Experiments (DoE) contains techniques, such as factorial designs, that help experimenters maximize the information output from conducted experiments and minimize the amount of experimental work required to reach statistically significant results. The use of DoE in industrial processes is frequently and thoroughly described in literature. LÄS MER

  4. 4. Experimental Designs at the Crossroads of Drug Discovery

    Författare :Ing-Marie Olsson; Svante Wold; Johan Gottfries; Michael Sjöström; Bo Nordén; Umeå universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; Organic chemistry; Organisk kemi;

    Sammanfattning : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. LÄS MER

  5. 5. On design of experiments in continuous processes

    Författare :Erik Vanhatalo; Luleå tekniska universitet; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Kvalitetsteknik; Quality Technology and Management;

    Sammanfattning : Design of Experiments (DoE) includes powerful methods, such as factorial designs, to help maximize the information output from conducted experiments while minimizing the experimental work required for statistically significant results. The benefits of using DoE in industry are thoroughly described in the literature although the actual use of the methods in industry is far from being pervasive. LÄS MER