Sökning: "Svante Wold"

Hittade 4 avhandlingar innehållade orden Svante Wold.

  1. 1. Multivariate methods in tablet formulation

    Författare :Jon Gabrielsson; Michael Sjöström; Svante Wold; Torbjörn Lundstedt; Marc Brown; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; PCA; statistical experimental design; multivariate design; PLS; excipients; direct compression; tablet formulation; robustness testing; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes the application of multivariate methods in a novel approach to the formulation of tablets for direct compression. It begins with a brief historical review, followed by a basic introduction to key aspects of tablet formulation and multivariate data analysis. LÄS MER

  3. 2. Experimental Designs at the Crossroads of Drug Discovery

    Författare :Ing-Marie Olsson; Svante Wold; Johan Gottfries; Michael Sjöström; Bo Nordén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; Organic chemistry; Organisk kemi;

    Sammanfattning : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. LÄS MER

  4. 3. Deciphering sequence data : A multivariate approach

    Författare :Maria Sandberg Hiltunen; Michael Sjöström; Svante Wold; Lars Ståhle; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Principal properties; amino acids; nucleotides; tRNA; DNA; multivariate data analysis; sequence analysis; QSAR; quantitative sequence activity relationships;

    Sammanfattning : In this thesis, attention has been focused on the quantitative description of nucleic acids, proteins and peptides. The strategy was to use multivariate chemometrical methods for improving the understanding of the complex structural codes of these kinds of biological molecules. LÄS MER

  5. 4. Nonionic surfactants : A multivariate study

    Författare :Lise-Lott Uppgård; Michael Sjöström; Svante Wold; Jiri Damborsky; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AEO; APG; aquatic toxicity; cellulose reactivity; Fock; MLR; multivariate data analysis; nonionic surfactant; PCA; physicochemical properties; PLS; QSAR; surface activity; viscose; Chemistry; Kemi;

    Sammanfattning : In this thesis technical nonionic surfactants are studied using multivariate techniques. The surfactants studied were alkyl ethoxylates (AEOs) and alkyl polyglucosides (APGs). The aquatic toxicity of the surfactants towards two organisms, a shrimp and a rotifer, was examined. The specified effect was lethality, LC50, as indicated by immobilisation. LÄS MER