Sökning: "Assay optimisation"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden Assay optimisation.

  1. 1. Experimental Designs at the Crossroads of Drug Discovery

    Detta är en avhandling från Umeå : Kemi

    Författare :Ing-Marie Olsson; Umeå universitet.; [2006]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemometrics; Design of experiments; Experimental design; Multivariate data-analysis; D-optimal design; 96-well technology; Drug discovery; Assay optimisation; QSAR; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi;

    Sammanfattning : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. LÄS MER

  2. 2. Optimisation of Chemotherapy Treatment in Advanced Colorectal Cancer

    Detta är en avhandling från Uppsala : Eklundshof Grafiska AB

    Författare :Åke Berglund; Uppsala universitet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Colorectal cancer; chemotherapy; 5-fluorouracil; dose-effect relationship; ex vivo assay; thymidylate synthase; p53; CEA; TPS; VEGF; bFGF.; Onkologi; MEDICINE Surgery Oncology; MEDICIN Kirurgi Onkologi; Oncology; onkologi;

    Sammanfattning : Colorectal cancer is one of the most common malignant diseases in Sweden – more than 5000 new cases are diagnosed each year. The overall five-year survival is about 60% and in cases of recurrence the prognosis is poor. LÄS MER

  3. 3. Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis

    Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Microbiology, Tumor and Cell Biology

    Författare :Gunnel Lindegren; Karolinska Institutet.; Karolinska Institutet.; [2008]

    Sammanfattning : Dengue fever (DF) is the most common global viral mosquito-borne infection, with 100 million estimated cases annually in tropical and subtropical areas. The dengue viruses (genus Flavivirus, Flaviviridae) occur in 4 serotypes (DENV-1 to DENV-4). Dengue diseases range from a mild febrile disease to severe hemorrhagic fever. LÄS MER

  4. 4. Estimation of acute toxicity by using the differentiated neuronal progenitor C17.2 cell model

    Detta är en avhandling från Department of Neurochemistry, Stockholm University

    Författare :Jessica Lundqvist; Stockholms universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Neurotoxicity; C17.2; cell membrane potential; Optimisation culture condition; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Sammanfattning : The authorities in Europe and United States request information regarding possible toxicity for substances that are produced in one tonne or more per year. Estimation of acute systemic toxicity is conducted in vivo using mice or rats. LÄS MER

  5. 5. Sensitive Forensic DNA Analysis Application of Pyrosequencing and Real-time PCR Quantification

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Hanna Andréasson; Uppsala universitet.; [2005]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; forensic; sensitive DNA analysis; DNA quantification; mtDNA; Real-time PCR; Pyrosequencing; Genetik; MEDICINE Dermatology and venerology; clinical genetics; internal medicine Clinical genetics; MEDICIN Dermatologi och venerologi; klinisk genetik; invärtesmedicin Klinisk genetik;

    Sammanfattning : The field of forensic genetics is growing fast and the development and optimisation of more sensitive, faster and more discriminating forensic DNA analysis methods is highly important. In this thesis, an evaluation of the use of novel DNA technologies and the development of specific applications for use in forensic casework investigations are presented. LÄS MER