Sökning: "DQB1"

Visar resultat 11 - 15 av 35 avhandlingar innehållade ordet DQB1.

1. 11. Aspects of ZnT8 autoimmunity in childhood type 1 diabetes

   Författare :Cecilia K Andersson; Pediatrisk endokrinologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Zinc transporter; ZnT8 autoantibodies; HLA; islet cell autoantibodies; GAD65 autoantibodies; IA-2 autoantibodies; insulin autoantibodies; glucose tolerance;

   Sammanfattning : Type 1 diabetes is one of the most common chronic diseases in childhood and adolescence with an increasing incidence worldwide. It is an autoimmune disease with many autoimmune markers, where the zinc transporter 8 autoantibody (ZnT8A) is the most recent autoantibody discovered. LÄS MER

3. 12. Studies on autoimmune diabetes in Latvians and other populations

   Författare :Aija Shtauvere-Braméus; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : IDDM is an autoimmune disease, characterized by autoimmune mediated loss of insulin secreting B- cells. GAD65 and IA-2 are major B-cell specific autoantibodies and are not found in healthy population. IDDM is associated with certain HLA class II alleles. IDDM is positively associated with HLA DR3 and DR4 in Caucasians. LÄS MER

4. 13. Molecular mechanisms of HLA associations with myasthenia gravis

   Författare :Peter Hjelmström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Myasthenia gravis; MHC; HLA; T cell receptor; acetylcholine receptor; TNF-a; thymus complex disease trait; autoimmunity; molecular modelling; stratification; DNA polymorphisms;

   Sammanfattning : Myasthenia gravis (MG) is a neuromuscular disease characterised by muscle weakness due to an autoimmune attack against the nicotinic acetylcholine receptor (nAChR). MG has a complex pattern of inheritance and several genetic and environmental factors are important in conferring susceptibility to the disease. LÄS MER

5. 14. Genetic interaction between Type 1 and Type 2 diabetes

   Författare :Haiyan Li; Malmö Institutionen för kliniska vetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocrinology; IDDM2.; Insulin gene VNTR; HLA; IDDM1; mixed type 1 2; Mixed type 1 type 2 diabetes families; LADA; GADabs; Autoantibodies against GAD65; Type 1 diabetes; Type 2 diabetes; diabetology; secreting systems; sekretion; diabetologi; Endokrinologi;

   Sammanfattning : There are two major types of diabetes, type 1 and type 2 diabetes. Similarly characterized by hyperglycaemia and long term micro- and macrovascular complications, type 1 and type 2 diabetes have different underlying pathophysiologic processes. In Scandinavia, type 1 diabetes is common; type 2 diabetes accounts for 85% of all cases with diabetes. LÄS MER

7. 15. Immunogenetics of Type 1 diabetes and Celiac disease

   Författare :Shehab Abdulaziz Alshiekh; Celiaki och diabetes; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; celiac disease; type 1 diabetes; children; genetics; human leukocyte antigen; next generation sequencing;

   Sammanfattning : AbstractThe primary purpose of understanding disease etiology is to explain how a specific phenotype is determined by genotype. In pursue of this aim, exploring the diversity in DNA sequence variants that affect biomedical traits, especially those related to the onset and progression of genetically determined human disease. LÄS MER