Avancerad sökning

Hittade 5 avhandlingar som matchar ovanstående sökkriterier.

1. 1. On approximations and computations in probabilistic classification and in learning of graphical models

   Författare :Magnus Ekdahl; Jose Antonio Lozano; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mathematical statistics; factorizations; probabilistic classification; nodes; DNA strings; Mathematical statistics; Matematisk statistik;

   Sammanfattning : Model based probabilistic classification is heavily used in data mining and machine learning. For computational learning these models may need approximation steps however. LÄS MER

3. 2. On gene regulatory networks and data fitting

   Författare :Karl Fogelmark; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Nyckelord :Circadian rhythms; gene regulation; transcription networks; correlated data; Circadian rhythms; gene regulation; transcription networks; correlated data; Fysicumarkivet A:2016:Fogelmark;

   Sammanfattning : Living organisms can be viewed as complex biological machines. In order to function, they must regulate their internal mechanism to do the right thing, at the right time, and in the right amount. Part of this regulation is encoded in gene regulatory networks. LÄS MER

4. 3. Bio-inspired crossover and a model of neuronal reprogramming

   Författare :Adriaan Merlevede; Beräkningsbiologi och biologisk fysik - Genomgår omorganisation; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; evolutionary comuptation; crossover; genetic recombination; permutation; flexible genome; direct neuronal reprogramming;

   Sammanfattning : Bio-inspired crossover:Natural genomes are affected by various kinds of mutations, manifesting as variations in the genome. This includes modifications to individual base pairs (single nucleotide polymorphism, SNP), but also short insertions and deletions (indels), and variations in the position (translocations) or multiplicity (copy number variations) of genetic sequences. LÄS MER

5. 4. The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing

   Författare :Henrik Zetterquist; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Clinical transplantation; HLA; histocompatibility testing; PCR; allele-specific amplification; sequence-specific primers; bone marrow transplantation; mixed chimerism; minimal residual disease; acute lymphoblastic leukemia;

   Sammanfattning : Transplantation immunology basically deals with the immune mechanisms that lead to rejection of transplanted tissues. Lymphocytes are the key mediators of graft rejection. At the time for this observation, the genetic loci responsible for histocompatibility between individuals of the same species were already identified in the mouse. LÄS MER

7. 5. On the molecular mechanisms of the amyloid β-peptide aggregation

   Författare :Kalyani Sanagavarapu; NanoLund: Centre for Nanoscience; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; amyloid β-peptide; aggregation kinetics; aggregation mechanism N-terminus; mutations; variants; sequence determinants; ; cross-seeding;

   Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER