Sökning: "Cytochrome P450 enzymes"

Visar resultat 11 - 15 av 101 avhandlingar innehållade orden Cytochrome P450 enzymes.

  1. 11. Mass Spectrometric Analysis of Oxylipins : Application to Cytochrome P450-Dependent Metabolism

    Författare :Tomas Nilsson; Ernst Oliw; Johan Bylund; Mikael Hedeland; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epoxyalcohols; fatty acids; hydroperoxides; electrospray ionization; ichthyosis; CYP4; linear ion trap; fragmentation mechanism; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biochemical Pharmacology; Biokemisk farmakologi;

    Sammanfattning : Cytochrome P450 (CYP) family 4 constitutes monoxygenases responsible for hydroxylation of fatty acids and other lipids. For example, CYP4F3 metabolizes leukotrienes and CYP4F8 prostaglandin H. Importantly, six of the twelve CYP4 enzymes are orphans, i.e. LÄS MER

  3. 12. Cytochrome P450 Enzymes in the Metabolism of Vitamin D3

    Författare :Fardin Hosseinpour; Leif Bertilsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biochemistry; biokemi;

    Sammanfattning : A cytochrome P450 enzyme in pig kidney that catalyzes the hydroxylations of vitamin D3 and C27-sterols was cloned. DNA sequence analysis of the cDNA revealed that the enzyme belongs to the CYP27 family. The recombinant kidney CYP27A enzyme catalyzed the 25-hydroxylation of vitamin D3 and the 27-oxygenation of C27-sterols. LÄS MER

  4. 13. Cytochrome P450 enzymes in the bioactivation of vitamin D

    Författare :Eva Axén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  5. 14. Qualitative and Quantitative Assessment of Cytochromes P450 mRNA in Human : Studies in the Liver, Blood and Gastrointestinal Mucosa

    Författare :Mari Thörn; Lars Lööf; Anders Rane; Ellen Vinge; Uppsala universitet; []
    Nyckelord :Medical sciences; cytochrome P450; CYP1A2; CYP1B1; CYP2E1; CYP3A4; CYP3A5; P-gp; gene expression; RT-PCR; liver; blood; gastrointestinal mucosa; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Sammanfattning : Drugs and other foreign compounds must often be metabolised before they can be excreted from the body. One enzyme system that is responsible for this is the cytochrome P450 gene family (CYP). LÄS MER

  7. 15. Growth hormone regulation of hepatic drug-metabolising enzymes in humans and rats

    Författare :Eva Rasmussen; Uppsala universitet; []
    Nyckelord :Medical sciences; growth hormone; IGF-I; somatostatin; cytochrome P450; regulation; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : There are pronounced sex-differences in the gene expression of several liver enzymes in the rat. The sex-differentiated secretion of growth hormone (GH) regulates these differences. We wanted to further investigate the mechanisms of this regulation in rats and to study the GH regulation of drug metabolism in man. LÄS MER