Sökning: "CYP3A5"

Visar resultat 1 - 5 av 17 avhandlingar innehållade ordet CYP3A5.

  1. 1. Qualitative and Quantitative Assessment of Cytochromes P450 mRNA in Human : Studies in the Liver, Blood and Gastrointestinal Mucosa

    Författare :Mari Thörn; Lars Lööf; Anders Rane; Ellen Vinge; Uppsala universitet; []
    Nyckelord :Medical sciences; cytochrome P450; CYP1A2; CYP1B1; CYP2E1; CYP3A4; CYP3A5; P-gp; gene expression; RT-PCR; liver; blood; gastrointestinal mucosa; MEDICIN OCH VÅRD; MEDICINE; MEDICIN;

    Sammanfattning : Drugs and other foreign compounds must often be metabolised before they can be excreted from the body. One enzyme system that is responsible for this is the cytochrome P450 gene family (CYP). LÄS MER

  3. 2. The role of CYP3A4/5 in alprazolam metabolism

    Författare :Annika Allqvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black populations. LÄS MER

  4. 3. Pharmacogenetics of human cytochrome P450 3A (CYP3A) enzymes

    Författare :Anna Westlind Johnsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The cytochrome P450 3A (CYP3A) subfamily encompasses the most important CYP enzymes with respect to drug metabolism, in particular CYP3A4. responsible for the metabolism of a majority of drugs being metabolized in order to be excreted. LÄS MER

  5. 4. Pharmacogenetic aspects of HIV/AIDS, tuberculosis and malaria : emphasis on Ugandan population

    Författare :Jackson Kijumba B Mukonzo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Infectious diseases such as HIV, tuberculosis and malaria are endemic in Africa and often require concomitant treatments that may result into subsequent drug–drug interactions. Inter-individual variability in the pharmacokinetics and pharmacodynamics of drugs used in infectious diseases, as a result of genetic polymorphism, has been reported. LÄS MER

  7. 5. Genetically determined interindividual variation in cytochrome P450 dependent drug metabolism : molecular basis and clinical implications

    Författare :Sarah C Sim; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pharmacogenetics is the study of genetic variation that causes variation in drug levels (pharmacokinetics), drug response (pharmacodynamics) and adverse drug reactions. Pharmacogenetics aims at identifying biomarkers that allows a personalized drug treatment and thereby increased drug efficacy and reduced occurrence of adverse drug reactions. LÄS MER