Sökning: "Clˉ homeostasis"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden Clˉ homeostasis.

  1. 1. Chloride ion dynamics in neuronal homeostasis and plasticity: Measuring a zero current with a twitch of learning

    Författare :Christer Fåhraeus; Hjärnans sensorimotoriska funktioner; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; K-Cl cotransporter; Clˉ homeostasis; DIDS; SITS; bumetanide; mathematical modeling; intracellular glass microelectrode; electrodiffusion; electro-osmosis; tip potential; Hebb; learning;

    Sammanfattning : .... LÄS MER

  3. 2. Chloride Homeostasis in Central Neurons

    Författare :Tushar Yelhekar; Staffan Johansson; Michael Druzin; Merab Kokaia; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chloride concentration; current-voltage relation; interpolation; voltage ramp; reversal potential; [Cl–]i recovery; KCC2; extracellular matrix; GABAA receptor; chloride leak conductance; neurosteroid; fysiologi; Physiology;

    Sammanfattning : The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function. Normal function of the central nervous system (CNS) depends on a delicate balance between neuronal excitation and inhibition. LÄS MER

  4. 3. Ion homeostasis in control of stem cell proliferation

    Författare :Shaimaa Abdelhady; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The ion homeostasis is critically maintained in all cells by a combined effort from various ion channels, transporters, pumps, and gap junctions. Ion fluxes are essential in excitable cells as they regulate the excitability of the cells and initiate and propagate action potentials. LÄS MER

  5. 4. Applying the Pump and Leak Hypothesis. An experimental and theoretical investigation of the principles of ion regulation and excitability in the crustacean stretch receptor neuron

    Författare :Sten Theander; Människan i rörelse: hälsa och rehabilitering; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; lobster; stretch receptor neuron; leak current; Q-current; K-Cl cotransporter; A-current; mathematical model; excitability; GABA channel; neurophysiology; ion regulation; neuropsykologi; Neurologi; neurofysiologi;

    Sammanfattning : An invertebrate nerve cell preparation, the lobster stretch receptor neuron, was investigated with respect to maintenance of its resting voltage, intracellular ion concentrations and excitability using voltage clamp technique and ion-selective microelectrodes. It was found that the resting voltage (-65 mV) of microelectrode impaled cells is caused by (a) a homogenous population of K+ channels which we denoted as leak channels (b) an electrogenic and voltage-dependent Na-K pump current and (c) an inward microelectrode-induced "impalement" current carried mainly by Na+. LÄS MER

  7. 5. Mechanisms of Brain Damage Following Focal Cerebral Ischemia: Changes in Ion Homeostasis and the Importance of Free Radical Formation

    Författare :Gunilla Gidö; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBN; free radicals; potassium; extracellular calcium; neuronal damage; energy-depletion; hypoglycemia; Cerebral focal ischemia; spreading depression; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. LÄS MER