Sökning: "KCC2"

Hittade 3 avhandlingar innehållade ordet KCC2.

  1. 1. Chloride Homeostasis in Central Neurons

    Författare :Tushar Yelhekar; Staffan Johansson; Michael Druzin; Merab Kokaia; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; chloride concentration; current-voltage relation; interpolation; voltage ramp; reversal potential; [Cl–]i recovery; KCC2; extracellular matrix; GABAA receptor; chloride leak conductance; neurosteroid; fysiologi; Physiology;

    Sammanfattning : The overall aim of the present thesis is to clarify the control of intracellular chloride homeostasis in central neurons, because of the critical role of chloride ions (Cl–) for neuronal function. Normal function of the central nervous system (CNS) depends on a delicate balance between neuronal excitation and inhibition. LÄS MER

  3. 2. Cytoskeleton-interacting proteins in brainstem development : roles of KCC2 and Vangl2

    Författare :Zachi Horn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The brainstem is the most evolutionary conserved division of the brain. It develops from the hindbrain and midbrain regions of the neural tube and forms neural networks that regulate vital functions of the body. One of the most critical roles is to generate respiratory rhythm for the regulation of oxygen, carbon dioxide and pH levels. LÄS MER

  4. 3. Early function of KCC2 and Wnt genes : cytoskeletal effects in neural stem cells

    Författare :Zachi Horn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : From closure of the neural tube until formation of neuronal networks, cells undergo several crucial changes which depend on the expression of many important molecules. GABA, the principal inhibitory neurotransmitter in the adult nervous system, acts as an excitatory signal during embryonic development. LÄS MER