Sökning: "ion regulation"
Visar resultat 1 - 5 av 131 avhandlingar innehållade orden ion regulation.
1. Voltage-Sensor Domains of Ion Channels : Physiology, Regulation, and Role in Disease
Sammanfattning : Brain function depends on the ability of neurons to sense and respond to electricity, which is mediated by small modules in the neuronal membrane called voltage-sensor domains (VSDs). Disruption of VSD function can cause neurological disease such as epilepsy. LÄS MER
2. Elucidating the molecular basis of Na+/H+ exchange
Sammanfattning : Solute carrier (SLC) transporters are membrane transport proteins, which catalyse the movement of nutrients, ions, and drugs across cell membranes. Here, I will present our contribution to understanding the mechanism of the sodium/proton exchangers (NHE), belonging to the SLC9 family of membrane transporters. LÄS MER
3. Plant Phosphoinositide Kinases. A Study of PtdIns 4-kinases and a PtdIns 4-phosphate 5-kinase
Sammanfattning : Phosphoinositides are of particular interest in signal transduction processes as they can be sequentially phosphorylated and used as precursors for the intracellular messengers inositol trisphosphate (InsP3) and diacylglycerol (DAG) that in turn affects calcium levels and protein kinase cascades, eventually leading to a physiological response. The activity and regulation of PtdIns 4-kinases and PtdInsP kinase was studied. LÄS MER
4. Studies of individual pancreatic -cells : Electrophysiological analysis of rhythmic behaviour and development of new techniques
Sammanfattning : The insulin concentration in blood varies periodically, which is believed to prevent down-regulation of the hormone receptors. Loss of the regular insulin oscillations is considered to be an early sign of developing diabetes. LÄS MER
5. Applying the Pump and Leak Hypothesis. An experimental and theoretical investigation of the principles of ion regulation and excitability in the crustacean stretch receptor neuron
Sammanfattning : An invertebrate nerve cell preparation, the lobster stretch receptor neuron, was investigated with respect to maintenance of its resting voltage, intracellular ion concentrations and excitability using voltage clamp technique and ion-selective microelectrodes. It was found that the resting voltage (-65 mV) of microelectrode impaled cells is caused by (a) a homogenous population of K+ channels which we denoted as leak channels (b) an electrogenic and voltage-dependent Na-K pump current and (c) an inward microelectrode-induced "impalement" current carried mainly by Na+. LÄS MER