Sökning: "Cancer drugs"

Visar resultat 1 - 5 av 498 avhandlingar innehållade orden Cancer drugs.

  1. 1. Quiescent cancer cells : Three-dimensional cell models for evaluation of new therapeutics

    Författare :Frida Ek; Mårten Fryknäs; Malin Jarvius; Rolf Larsson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; cancer cell quiescence; dormancy; three-dimensional; multicellular tumor spheroids; model development; cancer pharmacology; mitochondria; OXPHOS; colorectal carcinoma; hepatocellular carcinoma; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Inadequate metabolic conditions in solid tumors lead to the formation of quiescent cancer cells that are suspended in a transient cell cycle arrest. When conditions change, quiescent cancer cells can re-enter the cell cycle and cause recurrence. LÄS MER

  3. 2. Cancer in organ transplant recipients

    Författare :Caroline Stenman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; organ transplantation; skin cancer; heart transplantation; lung transplantation;

    Sammanfattning : Tens of thousands of transplantations are performed around the world each year. Organ transplant recipients (OTR) are obliged to receive life-long medical treatment with immunosuppressive drugs to ensure graft function. However, such medications entail an increased risk of developing a broad spectrum of malignancies, especially skin cancer. LÄS MER

  4. 3. The proteasome as a target for cancer therapy

    Författare :Peter Larsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Cell viability assay; Chemotherapy; Drug repurposing; Genomic and transcriptomic signatures; Prognostic biomarkers; Proteasome; Proteasome genes; Proteasome inhibitors; Drug sensitivity biomarkers; Synergistic effect; Triple-negative breast cancer;

    Sammanfattning : The main objective of this PhD thesis was to evaluate the significance of proteasome genes as prognostic markers for different cancer types and identify specific cancer forms that respond to proteasome inhibition. The proteasome (PSM) plays an important role in maintaining cellular proteostasis and degrades the majority of proteins that require breakdown in the cell. LÄS MER

  5. 4. Patient-derived scaffolds as a 3D model for breast cancer

    Författare :Anna Gustafsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; patient-derived scaffolds; cancer microenvironment; 3D model; cancer stem cells; drug testing;

    Sammanfattning : Breast cancer is the most common cancer form in women worldwide. Many patients will have recurrent disease and more efficient targeted therapies are needed. The tumor microenvironment is a heterogenous complex mix of cells and components influencing critical cancer processes including progression, signaling and invasion. LÄS MER

  7. 5. Improved Nutritional Support in Cancer Patients

    Författare :Christina Persson; Ursula Falkmer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Oncology; Cancer; weight loss; PG-SGA; dietary advice; education; fish oil; melatonin; Onkologi; Oncology; Onkologi; Oncology; onkologi;

    Sammanfattning : Weight loss and other nutritional problems are common in cancer patients. The problems are of importance for response to treatment and survival and the well-being of the patients.Nutritional support can be carried out in different ways. LÄS MER