Sökning: "dynamic kinetic asymmetric transformation"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden dynamic kinetic asymmetric transformation.

  1. 1. Asymmetric transformation of ß- and γ-functionalized alcohols Study of combined ruthenium-catalyzed racemization and enzymatic resolution

    Detta är en avhandling från Stockholm : Department of Organic Chemistry, Stockholm University

    Författare :Annika Träff; Stockholms universitet.; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kinetic resolution; dynamic kinetic resolution; kinetic asymmetric transformation; dynamic kinetic asymmetric transformation; enzyme catalysis; racemization; asymmetric synthesis; chlorohydrin; cyano acetate; amino alcohol; metalloenzyme; bifunctional catalytic system; NATURAL SCIENCES Chemistry Organic chemistry Organic synthesis; NATURVETENSKAP Kemi Organisk kemi Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : The major part of this thesis describes the asymmetric synthesis of β- and γ-amino alcohols through the combination of ruthenium catalyzed racemization and enzymatic kinetic resolution.The dynamic kinetic resolution, DKR, protocol for chlorohydrins was improved by employing Bäckvall’s catalyst, which is a base activated racemization catalyst, in combination with Burkholderia cepacia lipase. LÄS MER

  2. 2. Chemoenzymatic Resolution in Dynamic Systems Screening, Classification and Asymmetric Synthesis

    Detta är en avhandling från Stockholm : KTH Royal Institute of Technology

    Författare :Yan Zhang; KTH.; [2013]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; constitutional dynamic chemistry; dynamic systemic resolution; dynamic kinetic resolution; enzyme catalysis; transesterification; enzyme promiscuity; asymmetric synthesis; pattern recognition; self-inhibition.;

    Sammanfattning : This  thesis  is  divided  into  four  parts,  all  centered  around  Constitutional Dynamic  Chemistry  (CDC)  and  Dynamic  Kinetic  Resolution  (DKR)  using biocatalysts for selective transformations, and their applications in screening of bioactive compounds, organic synthesis, and enzyme classification.   In  part  one,  an  introduction  to  CDC  and  DKR  is  presented,  illustrating  the basic  concepts,  practical  considerations  and  potential  applications  of  such dynamic systems, thus providing the background information for the studies in the following chapters. LÄS MER

  3. 3. Transition metal- and lipase-catalyzed reactions : Dynamic resolutions, hydrogen transfer and enzyme engineering

    Detta är en avhandling från Stockholm : Department of Organic Chemistry, Stockholm University

    Författare :Patrik Krumlinde; Stockholms universitet.; [2009]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dynamic kinetic resolution; dynamic kinetic asymmetric transformation; hydrogen transfer; directed evolution; enzyme engineering; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis mainly focuses on chemoenzymatic processes and can be divided into three parts: The first part of the thesis, chapters 2-4, is devoted to the development of combined ruthenium- and enzyme-catalyzed dynamic processes. In these processes the metal catalyst racemizes (epimerizes) the alcohol substrate via hydrogen transfer and the enzyme transforms the substrate into enantiomerically enriched product. LÄS MER

  4. 4. Enantioselective Synthesis of Sec-Alcohol Derivatives and Diols via Combined Ruthenium and Enzyme Catalysis

    Detta är en avhandling från Stockholm : Institutionen för organisk kemi

    Författare :Linnéa Borén; Stockholms universitet.; [2008]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; catalysis; kinetic resolution; ruthenium catalyst; Dynamic kinetic resolution; Dynamic Kinetic Asymmetric Transformation; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : The first part of this thesis describes the synthesis of enantiopure secondary alcohol derivatives. These syntheses are carried out via the combination of an enzyme as a resolution catalyst and a ruthenium catalyst as a racemization catalyst, in what is called dynamic kinetic resolution (DKR). LÄS MER

  5. 5. Synthetic Transformations via Metal- and Enzyme-Catalyzed Dynamic Kinetic Resolution

    Detta är en avhandling från Stockholm : Institutionen för organisk kemi

    Författare :Krisztián Bogár; Stockholms universitet.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ruthenium; racemization; lipase; dynamic kinetic resolution; secondary alcohol; Candida antarctica lipase B; NATURAL SCIENCES Chemistry Organic chemistry; NATURVETENSKAP Kemi Organisk kemi; Organic Chemistry; organisk kemi;

    Sammanfattning : This thesis deals with the preparation of a new half-sandwich type ruthenium(II)- catalyst for racemization of optically active secondary alcohols and the development of a highly efficient method in combination with lipases such as Candida antarctica lipase B and Pseudomonas cepacia lipase for dynamic kinetic resolution of various functionalized alcohols under mild reaction conditions.It was shown that the RuCl(CO)2(η5-C5Ph5) complex can racemize optically active aliphatic and aromatic secondary alcohols at room temperature in rather short times. LÄS MER