Sökning: "Brichos"
Visar resultat 1 - 5 av 16 avhandlingar innehållade ordet Brichos.
1. Islet amyloid polypeptide (IAPP) in Type 2 diabetes and Alzheimer disease
Sammanfattning : The misfolding and aggregation of the beta cell hormone islet amyloid polypeptide (IAPP) into amyloid fibrils is the main pathological finding in islets of Langerhans in type 2 diabetes. Pathological assemblies of IAPP are cytotoxic and believed to contribute to the loss of insulin-producing beta cells. LÄS MER
2. Of spiders, bugs, and men : Structural and functional studies of proteins involved in assembly
Sammanfattning : Protein assembly enables complex machineries while being economical with genetic information. However, protein assembly also constitutes a potential threat to the host, and needs to be carefully regulated.Sulfate is a common source of sulfur for cysteine synthesis in bacteria. LÄS MER
3. Advances in Ligand Binding Predictions using Molecular Dynamics Simulations
Sammanfattning : Biochemical processes all involve associations and dissociations of chemical entities. Understanding these is of substantial importance for many modern pharmaceutical applications. In this thesis, longstanding problems with regard to ligand binding are treated with computational methods, applied to proteins of key pharmaceutical importance. LÄS MER
4. Islet Amyloid Polypeptide: Interaction with Amyloid Beta, Alpha-Synuclein and BRICHOS
Sammanfattning : Amyloid, the congophilic deposits of misfolded protein, are pathological hallmarks of many common diseases, among others, Alzheimer’s disease (AD), Parkinson’s disease (PD), and type 2 diabetes (T2D). Amyloid beta (Aβ) forms senile plaques in AD, alpha-synuclein (aSyn) forms Lewy bodies and Lewy neurites in PD, islet amyloid polypeptide (IAPP) forms islet amyloid in T2D. LÄS MER
5. BRICHOS interactions with amyloid proteins and implications for Alzheimer disease
Sammanfattning : To date, about 30 diseases, in which amyloid fibrils form extracellular deposits, have been identified in humans. It is not known if the fibrils have a function, like storage of misfolded proteins, or if they just reflect failure of the cell to manage misfolded proteins. LÄS MER