Sökning: "adhesin"

Visar resultat 1 - 5 av 66 avhandlingar innehållade ordet adhesin.

  1. 1. Helicobacter pylori adhesion and patho-adaptation : the role of BabA and SabA adhesins in persistent infection and chronic inflammation

    Författare :Jafar Mahdavi; Henrik Clausen; Umeå universitet; []
    Nyckelord :H. pylori; BabA; adhesin; Lewis b; MUC5AC; sialyl-dimeric-Lewis x; chronic inflammation; SabA; Lewis x; LPS; odontologi; Odontology;

    Sammanfattning : Helicobacter pylori (H. pylori) is a human-specific gastric pathogen which is responsible for a spectrum of diseases ranging from superficial gastritis to gastric and duodenal ulceration, and which is also highly associated with gastric cancer. The pathogenesis of severe gastric disorders caused by H. LÄS MER

  3. 2. Adaptation of Helicobacter pylori Adherence Properties in Promotion of Host Tropism and Inflammatory Disease

    Författare :Marina Aspholm; Rino Rappuoli; Umeå universitet; []
    Nyckelord :H. pylori; BabA; SabA; adhesin; blood group antigens; sialylated; phase variation; hemagglutination; selectin; adaptation; odontologi; Odontology;

    Sammanfattning : Being among the most prevalent of persistent infectious agents in humans worldwide, Helicobacter pylori induces chronic inflammation (gastritis), which may progress to peptic ulceration and stomach cancer. The ability to adhere to the gastric mucosa is considered to be both a colonization and virulence property of H. pylori. For adherence, H. LÄS MER

  4. 3. Structural characterization of proteins to investigate their roles in diseases: Focus on MID & LTA4H

    Författare :Mahmudul Hasan; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Moraxella IgD binding protein; adhesin; leukotriene A4 hydrolase; small angle x-ray scattering; crystallography; circular dichroism;

    Sammanfattning : Protein molecules are responsible for many biological functions in cells. In order to fulfill their various biological roles, these chain-like molecules must fold into precise three-dimensional shapes. The knowledge of accurate molecular structures is a prerequisite for rational drug design and for structure based functional studies. LÄS MER

  5. 4. Revisiting dental caries as an immunodeficiency disorder

    Författare :Nongfei Sheng; Nicklas Strömberg; Anders Esberg; Thomas Boren; Anna Westerlund; Vuokko Loimaranta; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; caries; immunodeficiency; proline-rich proteins; DMBT1; S. mutans; adhesin; SpaP; Cnm; Cbm; collagen binding; caries risk stratification; precision dentistry;

    Sammanfattning : Worldwide, dental caries is the major human chronic disease, with billions of people affected in terms of life quality impairment and high society costs that consumes 5-10% of the global healthcare budget. In Western countries dental caries has declined dramatically, with a trajectory of 15% high-risk individuals with recurrent caries and a non-responder behavior to standard prevention. LÄS MER

  7. 5. Structural studies of the surface adhesin SspB from Streptococcus gordonii

    Författare :Nina Forsgren; Karina Persson; Inger Andersson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Streptococcus gordonii; X-ray crystallography; surface adhesin; dental plaque; structural biology; Structural biology; Strukturbiologi; ODONTOLOGY; ODONTOLOGI; odontologi; Odontology;

    Sammanfattning : Surface proteins on microorganisms that build up the oral biofilm are key players in the formation of the biofilm. Antigen I/II proteins are surface adhesins found on virtually all oral streptococci and share a conserved multi-domain architecture. These adhesins bind surface components on other bacteria and on host cells. LÄS MER