Sökning: "Antiretroviral Therapy"

Visar resultat 6 - 10 av 107 avhandlingar innehållade orden Antiretroviral Therapy.

1. 6. Pharmacometric Models to Improve Treatment of Tuberculosis

   Författare :Elin M Svensson; Mats O Karlsson; Maria C Kjellsson; Ulrika S H Simonsson; N. L’Ntshotsholé (Shasha) Jumbe; Uppsala universitet; []
   Nyckelord :pharmacokinetics; pharmacodynamics; population approach; nonlinear mixed-effects models; multidrug-resistant tuberculosis; bedaquiline; antiretroviral; drug-drug interactions; time-to-event; albumin; Klinisk farmakologi; Clinical Pharmacology;

   Sammanfattning : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. LÄS MER

3. 7. On HIV-1 infection in the central nervous system

   Författare :Åsa Mellgren; Göteborgs universitet; []
   Nyckelord :HIV-1; antiretroviral therapy; cerebrospinal fluid; neurofilament protein; AIDS dementia complex; neuropsychological test;

   Sammanfattning : HIV-1 (hereafter referred to as HIV) is a neurotropic virus that invades the central nervous system (CNS). The CNS is then susceptible to an acute infection and later to CNS opportunistic diseases and AIDS dementia complex (ADC). HIV does not infect the neurons, and neuropathogenesis is largely mediated by the immune system. LÄS MER

4. 8. On HIV in the elderly and vitamin B metabolism in HIV infection

   Författare :Erika Tyrberg; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; elderly; drug levels; potential drug-drug interactions; inflammation; immune activation; antiretroviral therapy; homocysteine; neurofilament light protein;

   Sammanfattning : The evolution of the human deficiency virus (HIV) field is unparalleled in the history of infectious diseases. From the first cases in the beginning of the 1980s, when an HIV diagnosis was a death sentence, through the discovery of the first effective medicines, up till today when people living with HIV (PLHIV) with access to antiretroviral therapy (ART) can lead a near normal life. LÄS MER

5. 9. Who died, where, when and why? : an investigation of HIV-related mortality in rural South Africa

   Författare :Paul Mee; Peter Byass; Mark A Collinson; Sangeetha Madhavan; Frank Tanser; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV; AIDS; Mortality; Determinants; Risk Factor; Spatial Epidemiology; Structural Determinant; Antiretroviral Therapy; Healthcare Access; South Africa; Sub-Saharan Africa; Traditional Medical Practitioner; Traditional Medicine; Tuberculosis; Health and Demographic Surveillance System; Global Health; Population Health; Epidemiology; Epidemiology; epidemiologi;

   Sammanfattning : BackgroundSouth Africa has experienced the most severe consequences of the HIV/AIDS pandemic. Every community has been affected in some way, many experiencing huge increases in mortality,particularly before antiretroviral therapies (ART) were readily available. LÄS MER

7. 10. Applied Population Pharmacokinetic/ Pharmacodynamic Modeling of Antiretroviral and Antimalarial Drug Therapy

   Författare :Daniel Röshammar; Göteborgs universitet; []
   Nyckelord :HIV; malaria; pharmacokinetics; pharmacodynamics; pharmacometrics; NONMEM;

   Sammanfattning : HIV/AIDS and malaria are two major global infectious diseases. Although better drugs against these conditions are becoming more available, dosages may not always be optimal with respect to effectiveness, safety, cost or convenience of administration. LÄS MER