Sökning: "Anna uppsala 2012"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Anna uppsala 2012.

1. 1. Design and Synthesis of Acyclic and Macrocyclic Peptidomimetics as Inhibitors of the Hepatitis C Virus NS3 Protease

   Författare :Anna Lampa; Anja Sandström; Youla Tsantrizos; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; hepatitis C virus; HCV; NS3 protease inhibitor; structure-activity relationship; phenylglycine; ring-closing metathesis; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Hepatitis C is a blood-borne disease affecting 130-170 million people worldwide. The causative agent, hepatitis C virus (HCV), infects the liver and is the major reason for chronic liver disease worldwide. The HCV NS3 protease, a key enzyme in the virus replication cycle, has been confirmed to be an important target for drug development. LÄS MER

3. 2. Genetic Characterization of Chicken Models for Autoimmune Disease

   Författare :Anna-Stina Sahlqvist; Olov Ekwall; Olle Kämpe; Leif Andersson; Susanne Kerje; Holger Luthman; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Autoimmune disease; Hashimoto’s thyroiditis; systemic sclerosis; comparative genomics; linkage analysis; OS chickens; spontaneous autoimmune thyroiditis; UCD-200 chickens.; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Autoimmune diseases are endemic, but the disease mechanisms are poorly understood. A way to better understand these are to find disease-regulating genes. However, this is difficult as the diseases are complex, with several genes as well as environmental factors influencing the development of disease. LÄS MER

4. 3. Studies of New Signal Transduction Modulators in Acute Myeloid Leukemia

   Författare :Anna Eriksson; Martin Höglund; Rolf Larsson; Bjørn Tore Gjertsen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Acute myeloid leukemia; Targeted therapies; Drug development; Tyrosine kinase inhibition; AKN-032; AKN-028; Internmedicin; Internal Medicine;

   Sammanfattning : Acute myeloid leukemia (AML) is a life-threatening malignant disorder with dismal prognosis. AML is characterized by frequent genetic changes involving tyrosine kinases, normally acting as important mediators in many basic cellular processes. LÄS MER

5. 4. First-pass Intestinal Metabolism of Drugs : Experiences from in vitro, in vivo and simulation studies

   Författare :Helena Anna Thörn; Hans Lennernäs; Paul Alfred Dickinson; Brian Houston; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; metabolism; CYP3A4; CYP2C9; CYP2D6; UGT; glucuronidation; physiologically based pharmacokinetic model; modelling; Biopharmaceutics; Biofarmaci;

   Sammanfattning : The bioavailability of a drug can be described as the fraction of an orally administered dose that reaches the systemic circulation and is often limited by first-pass metabolism in the gut and the liver. It is important to have knowledge about these processes since the systemic blood drug concentration is tightly connected to the effect of the drug. LÄS MER

7. 5. Dressing Up and the Art of Jamaica Kincaid

   Författare :Anna Borgström; Uppsala universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; Jamaica Kincaid; Art; Autobiography; Resistance to Categorization; Dressing Up; Cognizant Readings; Intertexts; Paratexts; English; Engelska;

   Sammanfattning : Whether her work is classified as fiction, biography, garden writing, or sketch, almost all ofJamaica Kincaid’s writing invokes the genre of autobiography. At the same time, she undercutsand complicates autobiographical readings of her work. LÄS MER