Sökning: "Susanne Kerje"

Hittade 5 avhandlingar innehållade orden Susanne Kerje.

1. 1. Mapping Genes Affecting Phenotypic Traits in Chicken

   Författare :Susanne Kerje; Leif Andersson; Martien Groenen; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; chicken; Quantitative Trait Loci; growth; egg production; epistasis; plumage colour; Extended black; MC1R; Dominant white; PMEL17; Genetik; Clinical genetics; Klinisk genetik;

   Sammanfattning : The purpose of gene mapping is to understand the underlying genetics of simple and complex traits like plumage colour and growth. This thesis is based on a cross between the wild ancestor of the modern chicken, the red junglefowl, and a White Leghorn line selected for high egg mass. LÄS MER

3. 2. Genetic Studies of Pigmentation in Chicken

   Författare :Ulrika Gunnarsson; Leif Andersson; Göran Andersson; Susanne Kerje; William J. Pavan; Uppsala universitet; []
   Nyckelord :;

   Sammanfattning : Domestic animals have been selected by humans for thousands of years, which have drastically altered their genetic constitution and phenotypes. In this thesis, several of the most important genes causing pigmentation differences between the wild red junglefowl (Gallus gallus) and domestic chickens have been identified. LÄS MER

4. 3. Factors Influencing Evolution to Antimalarial Drug Resistance in Plasmodium falciparum in Sudan and The Gambia

   Författare :Amany Kheir; Göte Swedberg; Susanne Kerje; Hamza Babiker; Staffan Svärd; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cross-mating; fitness; microsatellite haplotypes; mosquito infectivity; Infectious diseases; Infektionssjukdomar; Molekylär genetik; Molecular Genetics;

   Sammanfattning : Drug resistance is a major obstacle to management and control of malaria and currently progressing at a rapid rate across Africa. This thesis has examined factors influencing evolution of resistant P. falciparum at two sites in Africa, including parasite migration, cross mating and fitness cost of resistance. LÄS MER

5. 4. Animal genomics – gene discovery and gene characterization

   Författare :Rakan Naboulsi; Leif Andersson; Mårten Larsson; Susanne Kerje; Tosso Leeb; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Spontaneous autoimmune thyroiditis; SAT; Hashimoto’s thyroiditis; HT; Obese strain; transcriptional regulation; ZBED6; Igf2; miRNA; miR483; Whole-genome sequencing; RNA-seq; miRNA-seq;

   Sammanfattning : This thesis involves two projects. The aim in the first project was to identify genomic regions associated with spontaneous autoimmune thyroiditis (SAT), which is a hereditary autoimmune disease that affects the obese strain (OS) of chicken, an animal model for human Hashimoto’s thyroiditis (HT). LÄS MER

7. 5. Genetic Characterization of Chicken Models for Autoimmune Disease

   Författare :Anna-Stina Sahlqvist; Olov Ekwall; Olle Kämpe; Leif Andersson; Susanne Kerje; Holger Luthman; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Autoimmune disease; Hashimoto’s thyroiditis; systemic sclerosis; comparative genomics; linkage analysis; OS chickens; spontaneous autoimmune thyroiditis; UCD-200 chickens.; Molekylär medicin; Molecular Medicine;

   Sammanfattning : Autoimmune diseases are endemic, but the disease mechanisms are poorly understood. A way to better understand these are to find disease-regulating genes. However, this is difficult as the diseases are complex, with several genes as well as environmental factors influencing the development of disease. LÄS MER