Sökning: "systemic sclerosis"
Visar resultat 1 - 5 av 53 avhandlingar innehållade orden systemic sclerosis.
1. Systemic sclerosis : vascular, pulmonary and immunological aspects
Sammanfattning : In systemic sclerosis (SSc), interstitial lung disease (ILD) and engagement of the vascular system lead to increased morbidity and mortality. The aim of this thesis was to elucidate, in a consecutively included cohort of SSc (limited and diffuse) patients (n = 33), the T cell cytokine profile driving the disease in ILD and to explore the role of matrix metalloproteinase 9 (MMP-9) and its inhibitor: tissue inhibitor of metalloproteinase 1 (TIMP-1) in the extracellular matrix (ECM) degrading process leading to fibrous scarring and honey combing. LÄS MER
2. Systemic sclerosis : aspects on pathogenetic mechanisms
Sammanfattning : .... LÄS MER
3. Systemic sclerosis. Novel molecular and epidemiological features of disease
Sammanfattning : Systemic sclerosis (SSc) is a systemic rheumatic disease with significant mortality and morbidity. Different estimations of disease prevalence and incidence have been presented from various parts of the world. LÄS MER
4. Cardiovascular disease in systemic sclerosis
Sammanfattning : Systemic Sclerosis (SSc) is an autoimmune rheumatic disease, characterized by fibrosis of the skin and internal organs, vasculopathy and the production of autoantibodies. Cardiac and pulmonary disease manifestations are major causes of morbidity and mortality. LÄS MER
5. Genetic Analyses of Multiple Sclerosis and Systemic Lupus Erythematosus : From Single Markers to Genome-Wide Data
Sammanfattning : In autoimmune diseases an individual’s immune system becomes targeted at the body’s own healthy cells. The aim of this thesis was to identify genetic risk factors for the two autoimmune diseases multiple sclerosis (MS) and systemic lupus erythematosus (SLE). LÄS MER